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TGIF2 Antibody, FITC conjugated

  • 中文名稱：
    TGIF2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA884421LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TGIF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    5' TG 3' interacting factor 2 antibody; 5''-TG-3''-interacting factor 2 antibody; Homeobox protein TGIF2 antibody; TGF (beta) induced transcription factor 2 antibody; TGF beta induced factor 2 antibody; TGF-beta-induced transcription factor 2 antibody; TGFB induced factor 2 antibody; TGFB-induced factor 2 antibody; Tgif2 antibody; TGIF2_HUMAN antibody; Transforming growth factor beta induced factor 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein TGIF2 protein (82-222AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
  • 基因功能參考文獻(xiàn)：
    1. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. PMID: 27956704
    2. Authors suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC. PMID: 27712592
    3. Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells. PMID: 27448300
    4. expression of miR-148a was regulated by DNA methylation and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer PMID: 26638007
    5. miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2 PMID: 26464633
    6. Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea. PMID: 26330748
    7. Shows that the homologous mouse Tgif2 gene is necessary for gastrulation. PMID: 20040491

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  • 亞細(xì)胞定位：
    Nucleus. Note=Excluded from nucleoli.
  • 蛋白家族：
    TALE/TGIF homeobox family
  • 組織特異性：
    Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15764

    OMIM: 607294

    KEGG: hsa:60436

    STRING: 9606.ENSP00000362979

    UniGene: Hs.632264