TMEM175 Antibody
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中文名稱:TMEM175兔多克隆抗體
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貨號(hào):CSB-PA023756GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:TMEM175
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別名:TMEM175 antibody; Endosomal/lysosomal potassium channel TMEM175 antibody; Transmembrane protein 175 antibody; hTMEM175 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Human TMEM175
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB
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Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage.
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基因功能參考文獻(xiàn):
- TMEM175 deficiency impairs lysosomal and mitochondrial function and increases alpha-synuclein aggregation. PMID: 28193887
- structure of TMEM175 represents a novel architecture of a tetrameric cation channel whose ion selectivity mechanism appears to be distinct from that of the classical K(+) channel family PMID: 28723891
- Data indicated that GBA and TMEM175/GAK significantly alter age at onset in PD. PMID: 25914293
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