TONSL Antibody
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中文名稱:TONSL兔多克隆抗體
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貨號:CSB-PA286755
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規(guī)格:¥1100
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圖片:
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The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA286755(TONSL Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA286755(TONSL Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:TONSL
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別名:I kappa B related protein antibody; I-kappa-B-related protein antibody; IkappaBR antibody; IKBR antibody; Inhibitor of kappa B related protein antibody; Inhibitor of kappa B-related protein antibody; MMS22L-interacting protein antibody; MMS22L-interacting protein, NFBIL2/TONSL antibody; NF kappa B inhibitor like protein 2 antibody; NF-kappa-B inhibitor-like protein 2 antibody; NFBIL2 antibody; NFBIL2/TONSL antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2 antibody; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 antibody; Protein IkappaBR antibody; Tonsl antibody; TONSL_HUMAN antibody; Tonsoku-like protein antibody; tonsoku-like, DNA repair protein antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Fusion protein of Human TONSL
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:Antigen affinity purification
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,IHC
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推薦稀釋比:
Application Recommended Dilution ELISA 1:1000-1:5000 IHC 1:100-1:300 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
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基因功能參考文獻:
- By specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their homologous recombination-mediated restart in vivo. PMID: 27797818
- new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL-MMS22L homologous recombination complex PMID: 27338793
- Common NFKBIL2 polymorphisms are associated with susceptibility to invasive pneumococcal infection. PMID: 21171993
- Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. PMID: 21113133
- These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks. PMID: 21055983
- MMS22L and TONSL are required for the maintenance of genome stability. PMID: 21055984
- This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway. PMID: 21055985
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亞細(xì)胞定位:Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
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蛋白家族:Tonsoku family
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組織特異性:Expressed in heart, skeletal muscle and tracheal epithelial cells.
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數(shù)據(jù)庫鏈接:
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