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TOX3 Antibody

  • 中文名稱：
    TOX3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA024075LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western blot
      All lanes: TOX3 antibody at 9 μg/ml
      Lane 1: Mouse heart tissue
      Lane 2: Mouse spleen tissue
      Lane 3: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 63 kDa
      Observed band size: 63, 24 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA024075LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA024075LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TOX3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TOX3
  • 別名：
    BC052044 antibody; C230068E13 antibody; CAG trinucleotide repeat-containing gene F9 protein antibody; CAGF9 antibody; TNRC9 antibody; TOX high mobility group box family member 3 antibody; TOX3 antibody; TOX3_HUMAN antibody; Trinucleotide repeat containing 9 antibody; Trinucleotide repeat containing gene 9 protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human TOX high mobility group box family member 3 protein (8-305AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，TOX3 Antibody (CSB-PA024075LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于TOX3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA024075LB01HU TOX3 Antibody, HRP conjugated ELISA
    FITC CSB-PA024075LC01HU TOX3 Antibody, FITC conjugated
    Biotin CSB-PA024075LD01HU TOX3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
  • 基因功能參考文獻(xiàn)：
    1. there was a relationship between rs2046210 and rs3803662, and the risk of developing this disease in Vietnamese women. The A allele is the risk allele for both rs2046210 (OR [95% CI] = 1.43 [1.14 - 1.78], P = 0.0015) and rs3803662 (OR [95% CI] = 1.45 [1.16 - 1.83], P = 0.001). We conclude that two polymorphisms, rs2046210 in ESR1 and rs3803662 in TNRC9, are associated with breast cancer risk in the Vietnamese population. PMID: 30078824
    2. The results confirm the association between the TOX3 SNP rs3104767 and restless legs syndrome and suggest that TOX3 variants are involved in both RLS and Parkinson's disease, but with different or even opposite effects. PMID: 29404899
    3. This meta-analysis suggested that TOX3 rs3803662 polymorphism was associated with increased breast cancer risk. PMID: 29578175
    4. abnormal TOX3 methylation possibly resulting in changes in TOX3 protein expression is closely related to the occurrence of polycystic ovarian syndrome and may play a role the development of the pathology PMID: 28537684
    5. Data show that three SNPs (rs9933638, rs12443621, and rs3104746) at the TOX3/LOC643714 locus contributed to lung cancer risk, suggesting that lung cancer and breast cancer are linked at the molecular and genetic level to a certain extent. PMID: 27486757
    6. Data support a plausible molecular mechanism integrating epigenetic modifications of the TOX3 promoter and allele specific expression of SNPs in aggressive behavior of luminal breast tumors with high TOX3 expression. PMID: 27806084
    7. Significant associations were observed between Breast Cancer risk and two Single nucleotide polymorphisms of FGFR2 [rs2981582 (P=0.005), rs1219648 (P=9.08e006)] and one Single nucleotide polymorphisms of TNRC9 [rs3803662) (P=0.012)] in Pakistani women. PMID: 27572905
    8. The genotype of rs3803662 from TOX3 is associated with breast cancer. PMID: 26803517
    9. The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of breast cancer, in both Asian and Caucasian populations. PMID: 27525937
    10. TNRC9 GG genotype of rs3803662 is associated with increased breast cancer risk. PMID: 26911390
    11. The TOX3 SNPs rs3803662 C > T, rs12443621 A > G and rs8051542 C > T were all correlated with increased risk of breast cancer in the European and Asian populations, but not in the African one. PMID: 26239137
    12. TOX3 and FGFR2 are breast cancer susceptibility genes in BRCA1/2-wild-type breast cancer patients from Sardinian population. PMID: 25956309
    13. TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer PMID: 25632947
    14. Single nucleotide polymorphism in TOX3 gene is associated with breast cancer risk. PMID: 25531440
    15. data suggest that central inhibition of IL-1alpha or Tox3 overexpression during the acute phase of a CNS insult may be an effective means for preventing the loss of neurological function PMID: 26224856
    16. Mutations in TOX3 are not common in Chinese Han women with polycystic ovary syndrome. PMID: 25311971
    17. Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD PMID: 25142570
    18. These results indicate an additive effect of the TOX3 rs3803662 and 2q35 rs13387042 alleles for breast cancer risk. PMID: 24532140
    19. The T-rs8051542 allele was significantly associated with ER-positive and HER2-negative carriers. No significant association existed between rs12443621, rs3803662, and rs3112612 polymorphisms and risk of breast cancer. PMID: 24481062
    20. T allele and the TT genotype of the SNP rs38033662 is significantly associated with risk for breast cancer in Chinese Han women. PMID: 24446301
    21. mutations of TOX3 are present at low frequency in tumours. Our results support that TOX3 should be further investigated to elucidate its role in breast cancer biology. PMID: 24069272
    22. TOX3 rs3803662 might play an important role in the prognostic outcome and treatment of gastric cancer, especially perhaps further help in explaining the reduced risk of death associated with diffuse-type gastric cancer. PMID: 24069142
    23. TOX3 loci plays a role in the male breast cancer susceptibility. PMID: 23468243
    24. the minor allele of SNP rs3803662 was associated with shorter survival in breast cancer patients with luminal A tumours, with lower mRNA expression of TOX3 PMID: 23270421
    25. TNRC9 gene is amplified and associated with poor prognosis in advanced breast cancer. TNRC9 promotes cancer cell proliferation, migration, and survival both in vitro and in vivo. TNRC9 and BRCA1 expression are inversely correlated. PMID: 23447579
    26. Evidence of association with mammographic density was found for variant rs3803662 (TOX3). PMID: 23021931
    27. risk-associated SNPs modulate the affinity of chromatin for FOXA1 at distal regulatory elements, thereby resulting in allele-specific gene expression, which is exemplified by the effect of the rs4784227 SNP on the TOX3 gene within the 16q12.1 risk locus. PMID: 23001124
    28. Compared with TOX4, expression of TOX1, TOX2 and TOX3 in normal lung was 25, 44, and 88%lower, respectively, supporting the premise that reduced promoter activity confers increased susceptibility to methylation during lung carcinogenesis. PMID: 22496870
    29. Polymorphisms of trinucleotide repeat containing 9 gene is associated with breast cancer. PMID: 20703937
    30. TOX3 induces transcription in neuron depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. PMID: 21172805
    31. Suggest that genetic variants of TNRC9 may contribute to the development of estrogen receptor positive breast cancer in a Chinese population. PMID: 20213080
    32. Single nucleotide polymorphism in TOX3 is associated with breast cancer. PMID: 20406955
    33. findings strengthen the existing evidence that FGFR2-rs2981582 and TNRC9-rs3803662 are predominantly associated with ER-positive breast cancer PMID: 20664043
    34. Low-risk variants of TNRC9 is associated with familial breast cancer. PMID: 19856316
    35. Heterozygote carriers and minor allele homozygote carriers for SNP rs3803662 near the TNCR9 gene were more likely to be diagnosed before the age of 60 years (P = 0.025) relative to major allele homozygote carriers PMID: 17997823
    36. The polymorphism rs12443621 in TOX3 was associated with percent dense area in breast cancer. PMID: 19232126

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 11972

    OMIM: 611416

    KEGG: hsa:27324

    STRING: 9606.ENSP00000219746

    UniGene: Hs.132574