Your Good Partner in Biology Research

TPST1 Antibody

  • 中文名稱:
    TPST1兔多克隆抗體
  • 貨號(hào):
    CSB-PA024132GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    TPST1
  • 別名:
    TPST1; Protein-tyrosine sulfotransferase 1; Tyrosylprotein sulfotransferase 1; TPST-1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TPST1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
  • 基因功能參考文獻(xiàn):
    1. TPST1 was significantly negatively correlated with the expression of cMet in lung cancer and may be a negative prognostic biomarker of lung cancer. PMID: 26238632
    2. TPST1 rs3757417T>G polymorphisms are associated with colorectal cancer. PMID: 25079514
    3. Affinity purified salivary TPST showed a single band of 50-54 kDa and is the first report characterizing a tyrosylprotein sulfotransferase in secretory fluid from the parotid gland PMID: 16244708
    4. results exclude TPST1 as the causative gene for Shwachman-Diamond syndrome PMID: 12032733
    5. Shear stress-dependent downregulation of TPST1 in human endothelium involves protein kinase C PMID: 12056800
    6. Human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment. PMID: 16859706

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Protein sulfotransferase family
  • 組織特異性:
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 12020

    OMIM: 603125

    KEGG: hsa:8460

    STRING: 9606.ENSP00000302413

    UniGene: Hs.421194