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TRAF3IP3 Antibody, FITC conjugated

  • 中文名稱：
    TRAF3IP3兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA896865LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TRAF3IP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TRAF3IP3
  • 別名：
    TRAF3IP3 antibody; T3JAM antibody; TRAF3-interacting JNK-activating modulator antibody; TRAF3-interacting protein 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TRAF3-interacting JNK-activating modulator protein (74-185AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development. Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF. Plays also an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism. Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts. In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production. However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1.
  • 基因功能參考文獻(xiàn)：
    1. This paper provides an alignment of the mouse and human proteins. PMID: 14572659
    2. TRAF3IP3 stimulated cell growth by modulating the c-Jun N-terminal kinase (JNK) pathway PMID: 17868742
  • 亞細(xì)胞定位：
    Cell membrane. Golgi apparatus membrane; Single-pass type IV membrane protein. Lysosome membrane. Mitochondrion outer membrane.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30766

    OMIM: 608255

    KEGG: hsa:80342

    STRING: 9606.ENSP00000355991

    UniGene: Hs.147434