TRAPPC9 Antibody, HRP conjugated
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中文名稱:TRAPPC9兔多克隆抗體, HRP偶聯(lián)
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貨號:CSB-PA842741LB01HU
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) TRAPPC9 Polyclonal antibody
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Uniprot No.:
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基因名:TRAPPC9
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別名:TRAPPC9 antibody; KIAA1882 antibody; NIBP antibody; T1 antibody; Trafficking protein particle complex subunit 9 antibody; NIK- and IKBKB-binding protein antibody; Tularik gene 1 protein antibody
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宿主:Rabbit
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反應種屬:Human
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免疫原:Recombinant Human Trafficking protein particle complex subunit 9 protein (780-1030AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:HRP
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應用范圍:ELISA
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
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基因功能參考文獻:
- CNVs significantly contribute to the mutational spectrum of TRAPPC9 gene associated with syndromic intellectual disability. PMID: 29187737
- Data show that NIBP expression level is high in gastric cancer (GC) patients and indicate that the NIBPregulated NFkappaB signaling pathway plays a pivotal role in the chemoresistance of GC cells by promoting EMT. PMID: 29620292
- Homozygous TRAPPC9 gene nonsense mutation in OXTR gene is associated with intellectual disability, speech disorder, and secondary microcephaly. PMID: 29031008
- In this study, we report that WES analysis allowed identification of the causal molecular lesion in both patients. In the first family of Egyptian origin, a homozygous nonsense mutation (c.1423C>T; p.Arg377*) in TRAPPC9 was identified PMID: 27108886
- In conclusion, we demonstrated that NIBP knockdown reduces colorectal cancer metastasis through down-regulation of canonical NF-kappaBeta signaling and suppression of ERK and JNK signaling. PMID: 28125661
- NIBP impacts on the expression levels of Ecadherin, CD44 and vimentin via the NFkappaB classical and alternative pathways. PMID: 27109343
- NIBP reflects a higher metastatic potential of CRC tumors, and its mechanism of action may be through regulation of the classical NF-kappaB pathway and increased MMP-2 and MMP-9 expression PMID: 26596835
- Data identified important roles of NIBP in promoting tumorigenesis via NFkappaBeta signaling. PMID: 25704885
- Identification and construction of a 3D protein model of trafficking protein particle complex 9 (TRAPPC9), a potetnially interesting molecular target for the development of drug therapy against non syndromic mental retardation PMID: 24040793
- By detailed phenotypic analysis of our patients, and by critical literature review, we found that homozygous TRAPPC9 loss-of-function mutations cause a distinctive phenotype, characterized by peculiar facial appearance, obesity, hypotonia PMID: 22549410
- A homozygous splice site mutation in TRAPPC9 causes intellectual disability and microcephaly. PMID: 22989526
- Data suggest that TRAPPC9 serves to uncouple p150(Glued) from the COPII coat, and to relay the vesicle-dynactin interaction at the target membrane. PMID: 22279557
- Data show that a disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8. PMID: 21858081
- Studies indicate that a truncation of TRAPPC9 leads to mental retardation. PMID: 20966969
- TRAPPC9 has a role in brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex PMID: 20004763
- TRAPPC9, encodes the NIK- and IKK-beta-binding protein, has a role in nonsyndromic autosomal-recessive mental retardation PMID: 20004765
- NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation PMID: 15951441
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相關(guān)疾?。?/div>Mental retardation, autosomal recessive 13 (MRT13)亞細胞定位:Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm.蛋白家族:NIBP family組織特異性:Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.數(shù)據(jù)庫鏈接:
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