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TREH Antibody, Biotin conjugated

  • 中文名稱：
    TREH兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA024402LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TREH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TREH
  • 別名：
    Alpha alpha trehalase antibody; Alpha alpha trehalose glucohydrolase antibody; Alpha antibody; alpha-trehalase antibody; alpha-trehalose glucohydrolase antibody; Brush border membrane glycoprotein antibody; MGC129621 antibody; TRE antibody; TREA antibody; TREA_HUMAN antibody; TREH antibody; Trehalase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Trehalase protein (373-507AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
  • 基因功能參考文獻：
    1. these results indicate that trehalose has anti-apoptotic effects through the suppression of oxidative stress-induced mitochondrial injury and ER stress which is dependent on the promotion of autophagic flux and the induction of selective autophagy PMID: 28981117
    2. In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human Osteoarthritis, which may serve as a new target for future therapies. PMID: 27701424
    3. results suggest a significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population PMID: 26156397
    4. variants in TREH control trehalase activity, and although one of these variants is also reproducibly associated with T2D, it is likely that the effect of the SNP on risk of T2D occurs by a mechanism different than affecting trehalase activity. PMID: 23468175
    5. we found three protective alleles for glioma patients, including the allele ''T'' of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23-1.01; P = 0.05) analysis PMID: 22369735
    6. These results suggest that TREH acts as a stress-response protein in the kidney rather than involved in utilization of exogenous trehalose. PMID: 19126402

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  • 相關(guān)疾?。?/div>
    Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms.
  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Glycosyl hydrolase 37 family
  • 組織特異性：
    Expressed in kidney, liver and small intestine. Also more weakly expressed in pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12266

    OMIM: 275360

    KEGG: hsa:11181

    STRING: 9606.ENSP00000264029

    UniGene: Hs.129712