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TRIAP1 Antibody

  • 中文名稱：
    TRIAP1兔多克隆抗體
  • 貨號：
    CSB-PA024443ESR2HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA024443ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA024443ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TRIAP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TRIAP1
  • 別名：
    p53-inducible cell-survival factor antibody; p53CSV antibody; Protein 15E1.1 antibody; TP53-regulated inhibitor of apoptosis 1 antibody; TRIA1_HUMAN antibody; Triap1 antibody; WF 1 antibody; WF1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TP53-regulated inhibitor of apoptosis 1 protein (1-76AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.
  • 基因功能參考文獻：
    1. TRIAP1 is regulated by miR-320b and has a role in progression in nasopharyngeal carcinoma PMID: 27428374
    2. Results describe the upregulation of TRIAP1 in drugresistant breast cancer cells. Its experimental modulation changed breast tumor cells sensitivity to doxorubicin, thus confirming its role in drug resistance. PMID: 25998939
    3. TRIAP1 is Conserved Specific Coregulators of the p21:PUMA Expression Ratio. PMID: 23684607
    4. Under specific conditions of stress, p53 regulates transcription of p53CSV and that p53CSV is one of the important players in the p53-mediated cell survival. PMID: 15735003
    5. Upregulated in at least 50% of multiple myeloma cases tested. PMID: 19171422
    6. HSPC132 is p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway PMID: 15735003

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  • 亞細胞定位：
    Mitochondrion. Mitochondrion intermembrane space.
  • 蛋白家族：
    TRIAP1/MDM35 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26937

    OMIM: 614943

    KEGG: hsa:51499

    STRING: 9606.ENSP00000449795

    UniGene: Hs.69499