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TRPC4AP Antibody

  • 中文名稱：
    TRPC4AP兔多克隆抗體
  • 貨號：
    CSB-PA777153
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA777153(TRPC4AP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TRPC4AP
  • 別名：
    antibody; TRPC4AP antibody; Chromosome 20 open reading frame 188 antibody; Protein TAP1 antibody; Protein TRUSS antibody; Short transient receptor potential channel 4 associated protein antibody; Short transient receptor potential channel 4-associated protein antibody; TAP1 protein antibody; TNF receptor ubiquitous scaffolding/signaling protein antibody; TNF-receptor ubiquitous scaffolding/signaling protein antibody; TP4AP_HUMAN antibody; Transient receptor potential cation channel; subfamily C; member 4 associated protein antibody; Trp4 associated protein antibody; Trp4-associated protein antibody; Trpc4 associated protein antibody; Trpc4-associated protein antibody; TRPC4AP antibody; TRRP4AP antibody; TRUSS antibody; Tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human TRPC4AP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
  • 基因功能參考文獻：
    1. TRUSS is a novel substrate of E3 ligase Skp2. PMID: 26038816
    2. The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years. PMID: 19059308
    3. These findings suggest that TNF-R1, TRUSS, and TRPC4 augment Ca(2+) loading of endoplasmic reticulum Ca(2+) stores in the context of m1AchR stimulation PMID: 20458742
    4. TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus PMID: 20551172
    5. results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families PMID: 18449908

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  • 亞細胞定位：
    Cytoplasm, perinuclear region.
  • 數(shù)據庫鏈接：

    HGNC: 16181

    OMIM: 608430

    KEGG: hsa:26133

    STRING: 9606.ENSP00000252015

    UniGene: Hs.168073