Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Active thioredoxin with a redox potential of about -250 mV.
基因功能參考文獻:
TXNL1 is a novel regulatory molecule that inhibits cisplatin resistance in gastric cancer cells. PMID: 24525731
Distinct protein expression patterns, affecting TXNL1 and HDAC2, distinguish aneuploid with poor prognosis from diploid colorectal cancers. PMID: 21290163
Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein. PMID: 20455272
results imply that TRP-1 is a mammalian thioredoxin and plays as a transcriptional repressor through direct binding to the transcription factor B-Myb PMID: 16231315
TXNL1 acts as an effector of oxidants or a redox sensor by converting redox changes into changes of GDI capacity to capture Rab5, which in turn modulates fluid phase endocytosis PMID: 17987124
Txnl1 is the first example of a direct connection between protein reduction and proteolysis, two major intracellular protein quality control mechanisms. PMID: 19349277
TRP32 was identified as a novel subunit of the 26 S proteasome. PMID: 19349280
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亞細胞定位:
Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated.