Ttr Antibody
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中文名稱:Ttr兔多克隆抗體
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貨號:CSB-PA025270DA01MO
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Mus musculus (Mouse) Ttr Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:Ttr antibody; Transthyretin antibody; Prealbumin antibody
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宿主:Rabbit
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反應(yīng)種屬:Mouse
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免疫原:Recombinant Mouse Transthyretin protein (23-147AA)
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免疫原種屬:Mus musculus (Mouse)
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標記方式:Non-conjugated
本頁面中的產(chǎn)品,Ttr Antibody (CSB-PA025270DA01MO),的標記方式是Non-conjugated。對于Ttr Antibody,我們還提供其他標記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
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基因功能參考文獻:
- A C57BL/6 mouse line carrying the transthyretin (TTR) Gly83Arg gene mutation was successfully established. This strain of mice can be used for the study of hereditary vitreous amyloidosis. PMID: 29360446
- Results indicate that TTR stability is important for its recently described functions in assisting Abeta transport at the BBB and at the liver and also in regulating LRP1 levels and activity. TTR stabilization can serve as an avenue to increase both Abeta elimination and LRP1 levels, which in turn will further participate in Abeta clearance. PMID: 28570028
- This study reports a possible mechanism for Rhabdomyolysis-Induced Acute Kidney Injury and suggests that reductions in TTR could increase the generation of Reactive Oxygen Species and induce apoptosis. PMID: 29040977
- TTR neuritogenic activity is mediated by the megalin receptor and is lost in megalin-deficient neurons. PMID: 27518433
- New insights into ghrelin cell physiology, and given the known functions of RBP4 and TTR, support an emerging role for the ghrelin cell in blood glucose handling and metabolism. PMID: 23840311
- Transthyretin (TTR) deposition in the peripheral nervous system is the hallmark of familial amyloidotic polyneuropathy (FAP). PMID: 27568093
- TTR mediated transport of thyroxine represents a survival mechanism necessary for the myogenic program. PMID: 28075349
- provide evidence of a new role of Transthyretin as a transcription inducer of insulin-like growth factor receptor I in central nervous system, unveiling a new role in neuroprotection PMID: 25084758
- data also indicate that it is unlikely that the behaviors seen in Ttr(-/-) mice are related to its function PMID: 24956283
- Native transthyretin inhibits all preeclampsia-like features in the humanized mouse model. PMID: 24035612
- Transthyretin silencing (TTRkd) significantly reduced myogenin expression. PMID: 23717457
- Amyloid fibrils formed by a mutant form of TTR, A25T, activate microglia, leading to the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and nitric oxide. PMID: 24008733
- Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis. PMID: 23829269
- Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis. PMID: 23817086
- Increased degradation of 14-3-3zeta in lysosomes in the absence of TTR, increasing autophagy. PMID: 23523922
- our data demonstrate that the increased expression of Ttr in ob/ob mice does not cause (but rather attenuates) their phenotypic abnormalities. PMID: 22849972
- TTR has an important and nonredundant role in influencing the development of several organs. PMID: 23092911
- Results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon. PMID: 23108050
- TTR binds to Grp78 at the plasma membrane, is internalized into the beta-cell via a clathrin-dependent pathway, and that this internalization is necessary for the effects of TTR on beta-cell function. PMID: 22183612
- the expression of transthyretin and protein kinase Cgamma were increased in the prefrontal cortex but not in the hippocampus of naltrexone-treated mice PMID: 21111029
- Cerebrospinal fluid transthyretin contributes to control of neuronal cell death, edema and inflammation which influences the survival of endangered neurons in cerebral ischemia. PMID: 21044072
- Results identify transthyretin and Klotho as physiological targets of amyloid precursor protein that are regulated by soluble APPsbeta independent of developmental APP functions. PMID: 20855613
- TTR mRNA is dramatically up-regulated in the preimplantation mouse uterus as well as the progesterone-treated ovariectomized mouse uterus. PMID: 20188365
- Using transthyretin (TTR) KO mice as a model of augmented NPY levels, we showed that this strain has increased NPY content in the bone, further validating the expression of this neuropeptide by bone cells. PMID: 19954489
- Transthyretin is not required for thyroid hormone access to or distribution within the mouse brain. PMID: 12182890
- Levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system PMID: 15009661
- Mice overexpressing mutant APP have high levels of sAPPalpha & transthyretin & do not develop the tau phosphorylation or neuronal loss characteristic of human AD. Anti-transthyretin antibodies reverse this, showing that transthyretin is neuroprotective. PMID: 15342738
- Transthyretin is clearly not produced in the brain parenchyma of wild-type mice nor in transgenic mouse models of Alzheimer's disease. PMID: 16698124
- The effect of chronic ethanol treatment on transthyretin expression was analyzed because gamma-PKC mutants do not develop tolerance to chronic ethanol treatment. PMID: 16767509
- proliferation and apoptosis in the SVZ neural stem cell niche are differentially affected by the lack of TTR synthesis. PMID: 17574756
- Our results strongly suggest that TTR plays a critical role in modulating Abeta deposition in vivo. PMID: 17596449
- the absence of transthyretin does not seem to influence the regulation of lipid and glucose metabolism PMID: 17611908
- data show that the absence of TTR seems to accelerate the poorer cognitive performance normally associated with aging PMID: 17698379
- TTR participates in nerve physiology and enhances nerve regeneration PMID: 17897357
- Lowering TTR levels or interfering with retinol binding protein 4-TTR binding may enhance insulin sensitivity in obesity and type 2 diabetes PMID: 18285525
- TCDD can induce memory deficits by altering the estrogen pathways and a main route of TTR-mediated retinol transport. PMID: 18294692
- In mouse DRG, TTR mRNA was localized in the peripheral glial cells. PMID: 18406527
- Data show that the degree of total and vascular Abeta burdens in the aged Tg2576/TTR(-/-) mice is significantly reduced relative to the age-matched Tg2576/TTR(+/-) mice. PMID: 18429966
- TTR deposited in peripheral nervous system of familial amyloiditic polyneuropathy should be regarded as having blood or CSF origin PMID: 18835560
- Results suggest that transthyretin is up-regulated by estradiol via a pathway involving estrogen receptors alpha and beta. PMID: 19130215
- TTR has natural substrates in the nervous system PMID: 19138167
- Transthyretin, a gene previously suggested to play a role in the reduction of Alzheimer disease, has been identified as a leftward gene asymmetrically expressed in the brains of adult male mice. PMID: 19167467
- Axonal retrograde transport is impaired in transthyretin knock-out mice, in addition to neurite outgrowth impairment. PMID: 19279259
- Using both GFP-based and LacZ-based Cre reporter strains, we demonstrate that in Ttr::Cre transgenics, Cre-mediated recombination occurs throughout the visceral endoderm PMID: 19415627
- he alleged neuroprotective role of TTR in the nervous system should be regarded with caution and should not be generalized to all types of insults PMID: 19595729
- rat and murine TTR have a lower intrinsic beta-aggregation propensity and a similar native beta-structure stability compared with human TTR. PMID: 19602727
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亞細胞定位:Secreted.
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蛋白家族:Transthyretin family
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組織特異性:Detected in plasma (at protein level). Detected in liver.
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