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UBE2E3 Antibody, HRP conjugated

  • 中文名稱：
    UBE2E3兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA839280LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) UBE2E3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UBE2E3
  • 別名：
    Homologous to yeast UBC4/5 antibody; UB2E3_HUMAN antibody; UBC E4 antibody; Ubc M2 antibody; UBC4/5 homolog antibody; UBCE 4 antibody; UBCE4 antibody; UBCH 9 antibody; UbcH9 antibody; UbcM2 antibody; UBE2 E3 antibody; UBE2E3 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein E3 antibody; Ubiquitin conjugating enzyme E2 23 kDa antibody; Ubiquitin conjugating enzyme E2 E3 antibody; Ubiquitin conjugating enzyme E2E 3 (homologous to yeast UBC4/5) antibody; Ubiquitin conjugating enzyme E2E 3 (UBC4/5 homolog, yeast antibody; Ubiquitin conjugating enzyme E2E 3 antibody; Ubiquitin conjugating enzyme UBCH 9 antibody; Ubiquitin conjugating enzyme UBCH9 antibody; Ubiquitin protein ligase antibody; Ubiquitin protein ligase E3 antibody; Ubiquitin-conjugating enzyme E2 E3 antibody; Ubiquitin-conjugating enzyme E2-23 kDa antibody; Ubiquitin-protein ligase E3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-conjugating enzyme E2 E3 protein (2-128AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
  • 基因功能參考文獻：
    1. Cells depleted of UBE2E3 become senescent in the absence of overt DNA damage and have a distinct senescence-associated secretory phenotype, increased mitochondrial and lysosomal mass, an increased sensitivity to mitochondrial and lysosomal poisons, and an increased basal autophagic flux. PMID: 29879550
    2. Data indicate that ubiquitin-conjugating enzyme UBE2E3 and importin 11 (Imp-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (Nrf2) by restricting the transcription factor from partitioning to the mitochondria. PMID: 25378586
    3. UBE2E3 is essential for the proliferation of RPE-1 cells and is downregulated during RPE layer maturation in the developing mouse eye. PMID: 18614808
  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 組織特異性：
    Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12479

    OMIM: 604151

    KEGG: hsa:10477

    STRING: 9606.ENSP00000376215

    UniGene: Hs.470804