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UBE2L6 Antibody, FITC conjugated

  • 中文名稱：
    UBE2L6兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA025466LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) UBE2L6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    MGC40331 antibody; Retinoic acid induced gene B protein antibody; Retinoic acid-induced gene B protein antibody; RIG B antibody; RIG-B antibody; UB2L6_HUMAN antibody; UBCH 8 antibody; UbcH8 antibody; UBE2L6 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein L6 antibody; Ubiquitin conjugating enzyme E2L 6 antibody; Ubiquitin protein ligase antibody; Ubiquitin protein ligase L6 antibody; Ubiquitin-protein ligase L6 antibody; Ubiquitin/ISG15 conjugating enzyme E2 L6 antibody; Ubiquitin/ISG15-conjugating enzyme E2 L6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin/ISG15-conjugating enzyme E2 L6 protein (13-153AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
  • 基因功能參考文獻(xiàn)：
    1. Depletion of either ISG15 or UBE2L6/UBCH8 resulted in enhanced endogenous autophagic flux. PMID: 28186990
    2. Data indicate that reduced expression of the ubiquitin-conjugating enzyme UbcH8 protein correlated with poor outcome in nasopharyngeal carcinoma (NPC) patients. PMID: 26506425
    3. gain and loss-of-function approaches show that UBCH8 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation PMID: 20508617
    4. Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 knockdown, respectively. PMID: 15670748
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 組織特異性：
    Present in natural killer cells (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12490

    OMIM: 603890

    KEGG: hsa:9246

    STRING: 9606.ENSP00000287156

    UniGene: Hs.425777