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UBE2Q2 Antibody

  • 中文名稱：
    UBE2Q2兔多克隆抗體
  • 貨號：
    CSB-PA025475GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    UBE2Q2
  • 別名：
    LOC92912 antibody; UB2Q2_HUMAN antibody; UBE2Q2 antibody; Ubiquitin carrier protein Q2 antibody; Ubiquitin conjugating enzyme E2Q 2 antibody; Ubiquitin conjugating enzyme E2Q family member 2 antibody; Ubiquitin-conjugating enzyme E2 Q2 antibody; ubiquitin-conjugating enzyme E2Q (putative) 2 antibody; Ubiquitin-protein ligase Q2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UBE2Q2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.
  • 基因功能參考文獻(xiàn)：
    1. UBE2Q1 hypomethylation is associated with Colorectal Cancer. PMID: 26745068
    2. The newly characterized human gene, UBE2Q2, may have implications for the pathogenesis of acute lymphoblastic leukemia. PMID: 22642244
    3. In the 21 breast cancer cases investigated, a high increase in UBE2Q2 expression was found in 8 breast cancers (38.1%), a moderately increased UBE2Q2 expression was observed in 7 cases (33.3%), and no sig. changes were detected in 6 cases (28.6%). PMID: 20193842
    4. Found high expression levels of UBE2Q2 in human head and neck carcinoma cell lines and cancer tissues; found the level of UBE2Q2 is decreased in cell lines and cancer tissues that have resistance to CDDP or docetaxel. PMID: 19723876
    5. the novel LOC92912 gene is characterized. It is over-expressed in hypopharyngeal tumours. Its functions may be linked with the cytoskeleton; it may represent a new target for cancer therapeutics. PMID: 16300736
    6. Inhibition of the UBE2Q2 protein causes cells to undergo a prolonged prophase arrest suggesting that UBE2Q2 normally functions to antagonize an early mitotic checkpoint. PMID: 17471241

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 組織特異性：
    Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive epithelium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19248

    OMIM: 612501

    KEGG: hsa:92912

    STRING: 9606.ENSP00000267938

    UniGene: Hs.23033