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UNC5A Antibody

  • 中文名稱：
    UNC5A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA025628GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    UNC5A
  • 別名：
    FLJ16449 antibody; KIAA1976 antibody; Netrin receptor UNC 5A antibody; Netrin receptor UNC5A antibody; Netrin receptor Unc5h1 antibody; Protein unc-5 homolog 1 antibody; Protein unc-5 homolog A antibody; Unc 5 homolog 1 antibody; Unc 5 homolog A antibody; Unc 5 netrin receptor A antibody; Unc 5a antibody; Unc5 a antibody; Unc5 homolog 1 antibody; Unc5 homolog A antibody; Unc5a antibody; UNC5A_HUMAN antibody; Unc5h1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UNC5A-Specific
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
  • 基因功能參考文獻(xiàn)：
    1. Such data indicate that cooperation between the UPR and UNC5A depletion as previously observed by ourselves in HCC patients samples may foster liver cancer development and growth. PMID: 29277614
    2. UNC5A is capable of impeding autophagy and promoting HCV restriction through specific impact on virion infectivity, in a cell death-independent and DAPK-related manner. PMID: 28783179
    3. FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A. PMID: 24676280
    4. these data suggest an important role for UNC5A, a candidate tumor suppressor, in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer PMID: 24737586
    5. UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis PMID: 20372800
    6. may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis PMID: 12655055
    7. UNC5 orthologues define a new mechanism for both the positive (induction) and negative (suppression) regulation of apoptosis in cancer cells (review) PMID: 15573119

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell projection, neuron projection.
  • 蛋白家族：
    Unc-5 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12567

    OMIM: 607869

    KEGG: hsa:90249

    STRING: 9606.ENSP00000332737

    UniGene: Hs.33191