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UPF3A Antibody

  • 中文名稱：
    UPF3A兔多克隆抗體
  • 貨號：
    CSB-PA025652GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    UPF3A
  • 別名：
    2600001C03Rik antibody; 4930546M19Rik antibody; hUpf3 antibody; HUPF3A antibody; MGC151365 antibody; Nonsense mRNA reducing factor 3A antibody; OTTHUMP00000018789 antibody; Regulator of nonsense transcripts 3A antibody; REN3A_HUMAN antibody; RENT3A antibody; Up frameshift suppressor 3 homolog A antibody; Up-frameshift suppressor 3 homolog A antibody; UPF3 A antibody; UPF3 antibody; UPF3 regulator of nonsense transcripts homolog A antibody; upf3a antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UPF3A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
  • 基因功能參考文獻(xiàn)：
    1. The complex between the interacting domains of human UPF2 and UPF3b at a 1.95 A resolution. PMID: 15004547
    2. hUpf3a is much less active than hUpf3b to induce NMD and to stimulate translation PMID: 16601204
    3. The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm. PMID: 17803942
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
  • 蛋白家族：
    RENT3 family
  • 組織特異性：
    Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20332

    OMIM: 605530

    KEGG: hsa:65110

    STRING: 9606.ENSP00000364448

    UniGene: Hs.533855