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UQCRQ Antibody

  • 中文名稱：
    UQCRQ兔多克隆抗體
  • 貨號(hào)：
    CSB-PA025673GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Complex III subunit 8 antibody; Complex III subunit VIII antibody; Cytochrome b-c1 complex subunit 8 antibody; QCR8 antibody; QCR8_HUMAN antibody; QP-C antibody; QPC antibody; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein antibody; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C antibody; Uqcrq antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UQCRQ
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
  • 基因功能參考文獻(xiàn)：
    1. QP-C protein gene expression involved in the development of hyperpigmentation. PMID: 25950827
    2. Decreased electron Transport Complex III activity is associated with ulcerative colitis. PMID: 20440543
    3. We thus suggest that a homozygous mutation in UQCRQ is associated with defective function of mitochondrial complex III, leading to a severe autosomal-recessive neurological phenotype. PMID: 18439546
  • 相關(guān)疾?。?/div>
    Mitochondrial complex III deficiency, nuclear 4 (MC3DN4)
  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    UQCRQ/QCR8 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29594

    OMIM: 612080

    KEGG: hsa:27089

    STRING: 9606.ENSP00000367934

    UniGene: Hs.146602