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UROD Antibody

  • 中文名稱：
    UROD兔多克隆抗體
  • 貨號(hào)：
    CSB-PA025678GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    UROD
  • 別名：
    DCUP_HUMAN antibody; PCT antibody; UPD antibody; URO D antibody; URO-D antibody; urod antibody; Uroporphyrinogen decarboxylase antibody; Uroporphyrinogen III decarboxylase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human UROD
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  • 基因功能參考文獻(xiàn)：
    1. a new mutation in the UROD gene in Egyptian patients with Hepatoerythropoietic porphyria, is reported. PMID: 26789143
    2. a new insight in the conformational changes occurred in the mutant structures of UROD protein. PMID: 24777812
    3. Data suggest that the traditional Chinese medicine (TCM) candidate potential three-in-one inhibitors for three drug target proteins epidermal growth factor receptor (EGFR), Her2, and uroporphyrinogen decarboxylase (UROD) against head and neck cancer. PMID: 23140436
    4. Expression of the D306Y mutation results in an insoluble recombinant protein. G318R and K297N have little effect on the structure or activity of recombinant URO-D, but the proteins display reduced stability in vitro. PMID: 19656450
    5. Among seventeen F-PCT patients, sixteen UROD mutations were identified. PMID: 23545314
    6. analysis of uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine PMID: 23209648
    7. Mutations in UROD gene is associated with familial porphyria cutanea tarda. PMID: 22382040
    8. Hepatoerythropoietic porphyria and familial porphyria cutanea tarda G281E mutation in the uroporphyrinogen decarboxylase gene PMID: 21079081
    9. function of Arg37 in uroporphyrinogen III decarboxylase PMID: 20553007
    10. description of 3 siblings with hepatoerythropoietic porphyria; sequencing of the UROD gene revealed compound heterozygosity for a novel missense mutation, V166A, and a complex deletion/insertion, 645del1053ins10 PMID: 20479301
    11. Sequence deletions in uroporphyrinogen decarboxylase is associated with Porphyria Cutanea Tarda. PMID: 15046048
    12. we identified eight mutations in 18 previously unclassified porphyria cutanea tarda families PMID: 15186324
    13. Sequencing of the hydroxymethylbilane synthase and uroporphyrinogen decarboxylase genes confirmed the relatively rare diagnosis of dual porphyria, and revealed a novel uroporphyrinogen decarboxylase mutation PMID: 16390615
    14. There is a high degree of molecular heterogeneity of familial porphyria cutanea tarda in Spain and molecular genetic analysis is useful in distinguish between F-PCT and sporadic PCT. PMID: 17627795
    15. role of UROD mutations as a strong risk factor for porphyria cutanea tarda even in areas where environmental factors (hepatitis C virus) have been shown to be highly associated with the disease PMID: 19419417

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  • 相關(guān)疾?。?/div>
    Familial porphyria cutanea tarda (FPCT); Hepatoerythropoietic porphyria (HEP)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Uroporphyrinogen decarboxylase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12591

    OMIM: 176100

    KEGG: hsa:7389

    STRING: 9606.ENSP00000246337

    UniGene: Hs.78601