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USP20 Antibody

  • 中文名稱：
    USP20兔多克隆抗體
  • 貨號：
    CSB-PA896876LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • IHC image of CSB-PA896876LA01HU diluted at 1:200 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) USP20 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP20
  • 別名：
    Deubiquitinating enzyme 20 antibody; hVDU2 antibody; KIAA1003 antibody; LSFR 3A antibody; LSFR3A antibody; pVHL interacting deubiquitinating enzyme 2 antibody; Ubiquitin carboxyl terminal hydrolase 20 antibody; Ubiquitin carboxyl-terminal hydrolase 20 antibody; ubiquitin specific peptidase 20 antibody; Ubiquitin specific processing protease 20 antibody; Ubiquitin specific protease 20 antibody; Ubiquitin thioesterase 20 antibody; Ubiquitin thiolesterase 20 antibody; Ubiquitin-specific-processing protease 20 antibody; UBP20_HUMAN antibody; USP 20 antibody; USP20 antibody; VDU 2 antibody; VDU2 antibody; VHL interacting deubiquitinating enzyme 2 antibody; VHL-interacting deubiquitinating enzyme 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 protein (258-417AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，USP20 Antibody (CSB-PA896876LA01HU)，的標記方式是Non-conjugated。對于USP20 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA896876LB01HU USP20 Antibody, HRP conjugated ELISA
    FITC CSB-PA896876LC01HU USP20 Antibody, FITC conjugated
    Biotin CSB-PA896876LD01HU USP20 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能參考文獻：
    1. USP20 regulates actin cytoskeleton organization and cell migration in a manner dependent on ERK3 expression. The results identify USP20 as a bona fide regulator of ERK3 stability and physiological functions. PMID: 28167606
    2. we investigated the inter-action between PKM2 and USP20. Our results suggest a new molecular pathway in cancer metabolism through the regulation of PKM2. PMID: 25708858
    3. findings reveal a dynamic regulation of USP20 by site-specific phosphorylation as well as the interdependence of signal transduction and trafficking pathways in balancing adrenergic stimulation and maintaining cellular homeostasis PMID: 25666616
    4. data establish a new function of USP20 in genome maintenance and DNA repair. PMID: 24923443
    5. Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. PMID: 22552337
    6. Our results point to USP20 as a key negative regulator of HTLV-1 Tax-induced NF-kappaB signaling. PMID: 21525354
    7. identification and description of VDU2 in human cells PMID: 12865408
    8. von Hippel-Lindau protein-interacting deubiquitinating enzyme 2 (VDU2) deubiquitinates and stabilizes HIF-1alpha. PMID: 15776016
    9. USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface. PMID: 19424180

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  • 亞細胞定位：
    Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
  • 蛋白家族：
    Peptidase C19 family, USP20/USP33 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12619

    OMIM: 615143

    KEGG: hsa:10868

    STRING: 9606.ENSP00000313811

    UniGene: Hs.5452