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USP36 Antibody

  • 中文名稱：
    USP36兔多克隆抗體
  • 貨號：
    CSB-PA167070
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using USP36 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP36 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP36
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human USP36.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
  • 基因功能參考文獻：
    1. Together, our results reveal USP36 as a novel H2B deubiquitinase and shed light on its additional functions in regulating gene expression. PMID: 29274341
    2. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation. PMID: 27445338
    3. USP36 is a crucial and bono fide deubiquitinating enzyme controlling c-Myc's nucleolar degradation pathway PMID: 25775507
    4. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review] PMID: 23773437
    5. USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
    6. The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene. PMID: 22865700
    7. Study identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. PMID: 21268071
    8. DUB-1 is present ubuquitously within cells and has deubiitinating enzyme activity in vivo and in vitro. PMID: 15254734
    9. indentification of deubiquitinating enzyme activity of USP36 by analyzing its capability to cleave the ubiquitin PMID: 15809067
    10. USP36 is overexpressed in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients PMID: 18566677
    11. Results suggest that by deubiquitylating various nucleolar substrate proteins including nucleophosmin/B23 and fibrillarin, USP36 plays a crucial role in regulating the structure and function of nucleoli. PMID: 19208757
    12. Data suggest that nucleophosmin/B23 recruits USP36 to nucleoli, thereby serving as a platform for the regulation of nucleolar protein functions through ubiquitylation/deubiquitylation. PMID: 19679658

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  • 亞細胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Broadly expressed.
  • 數據庫鏈接：

    HGNC: 20062

    OMIM: 612543

    STRING: 9606.ENSP00000310590

    UniGene: Hs.464243