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VAC14 Antibody

  • 中文名稱：
    VAC14兔多克隆抗體
  • 貨號：
    CSB-PA600170LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunofluorescent analysis of Hela cells using CSB-PA600170LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) VAC14 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    VAC14
  • 別名：
    ArPIKfyve antibody; FLJ10305 antibody; FLJ36622 antibody; FLJ46582 antibody; MGC149815 antibody; MGC149816 antibody; OTTHUMP00000174908 antibody; Protein VAC14 homolog antibody; Tax1 (human T cell leukemia virus type I) binding protein 1 antibody; Tax1 (human T cell leukemia virus type I) binding protein 2 antibody; Tax1 binding protein 2 antibody; Tax1-binding protein 2 antibody; TAX1BP2 antibody; TRX antibody; VAC 14 antibody; vac14 antibody; Vac14 homolog (S. cerevisiae) antibody; Vac14 homolog antibody; VAC14_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein VAC14 homolog protein (333-523AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，VAC14 Antibody (CSB-PA600170LA01HU)，的標記方式是Non-conjugated。對于VAC14 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA600170LB01HU VAC14 Antibody, HRP conjugated ELISA
    FITC CSB-PA600170LC01HU VAC14 Antibody, FITC conjugated
    Biotin CSB-PA600170LD01HU VAC14 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
  • 基因功能參考文獻：
    1. The association data demonstrated strong correlations between rs8060947 and VAC14 expression and between rs8060947 and S. Typhi invasion. The direction of effects for the different alleles led to the hypothesis that reducing VAC14 expression would increase S. Typhi invasion. PMID: 28827342
    2. A genome-wide association study of a prospectively enrolled patient cohort identified an single nucleotide polymorphism in VAC14 that predicts sensitivity to docetaxel-induced peripheral neuropathy. PMID: 27143689
    3. Biallelic rare coding variants in VAC14 was identified in a female neonate with Yunis-Varon syndrome. Cultured patient fibroblasts exhibited a YVS-like vacuolation ameliorated by ML-SA1. PMID: 28635952
    4. The similar age of onset and neurological decline in the two unrelated children define a recessive disorder resulting from compound heterozygosity for deleterious variants of VAC14. PMID: 27292112
    5. Rab7 GAP TBC1D15 with Vac14. PMID: 24578385
    6. a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 abundance by attenuating Sac3 proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J. PMID: 20630877
    7. the PIKfyve-associated hVac14 protein has a major role in activating PIKfyve and thereby regulating PtdIns(3,5)P(2) synthesis and endomembrane homeostasis in mammalian cells PMID: 15542851
    8. describe a novel interaction between the PDZ domain of nitric oxide synthase and Vac14 PMID: 17161399
    9. demonstrate a coupling between the machinery for PtdIns(3,5)P2 synthesis and turnover achieved through a physical assembly of PIKfyve, ArPIKfyve, and Sac3. PMID: 17556371
    10. The authors data indicate that the PAS complex is organized to provide optimal PIKfyve functionality and is maintained via ArPIKfyve homomeric and heteromeric interactions. PMID: 18950639
    11. PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis PMID: 19840946

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  • 相關疾病：
    Striatonigral degeneration, childhood-onset (SNDC)
  • 亞細胞定位：
    Endosome membrane. Microsome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
  • 蛋白家族：
    VAC14 family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25507

    OMIM: 604632

    KEGG: hsa:55697

    STRING: 9606.ENSP00000261776

    UniGene: Hs.445061