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VBP1 Antibody

  • 中文名稱：
    VBP1兔多克隆抗體
  • 貨號：
    CSB-PA025808GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    VBP1
  • 別名：
    HIBBJ 46 antibody; HIBBJ46 antibody; PFD 3 antibody; PFD3 antibody; PFD3_HUMAN antibody; PFDN 3 antibody; PFDN3 antibody; Prefoldin 3 antibody; Prefoldin subunit 3 antibody; Prefoldin3 antibody; VBP 1 antibody; VBP-1 antibody; VBP1 antibody; VHL binding protein 1 antibody; VHL-binding protein 1 antibody; Von Hippel Lindau binding protein 1 antibody; Von Hippel-Lindau-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human VBP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
  • 基因功能參考文獻(xiàn)：
    1. Data show that von Hippel-Lindau-binding protein 1 (VBP1) enhances the stability of von Hippel-Lindau tumor suppressor protein (pVHL) and facilitates pVHL-mediated ubiquitination of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha). PMID: 29121446
    2. VBP1 acts together with p97 to regulate hMSH4 degradation. PMID: 23964080
    3. binds to HIF-1 alpha and regulates the function of HIF-1 alpha PMID: 12613020
    4. VBP1 and cullin2/von Hippel-Lindau are required for proper HIV-1 expression at a step between integrase-dependent proviral integration into the host genome and transcription of viral genes PMID: 17698809
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.
  • 蛋白家族：
    Prefoldin subunit alpha family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12662

    OMIM: 300133

    KEGG: hsa:7411

    STRING: 9606.ENSP00000286428

    UniGene: Hs.436803