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VEGFB Antibody

  • 中文名稱：
    VEGFB兔多克隆抗體
  • 貨號：
    CSB-PA004444
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot analysis of Jurkat cells using VEGF-B Polyclonal Antibody
    • Western Blot analysis of COLO 293T HELA cells using VEGF-B Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Vascular endothelial growth factor B antibody; Vascular endothelial growth factor-related factor antibody; VEGF B antibody; VEGF related factor antibody; VEGF-B antibody; VEGF-related factor antibody; Vegfb antibody; VEGFB_HUMAN antibody; VEGFL antibody; VRF antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human VEGF-B.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
  • 基因功能參考文獻(xiàn)：
    1. High plasma VEGF-B levels are associated with type 2 diabetes mellitus. PMID: 28523459
    2. Data from clinical studies point out the changes in circulating or tissue expression levels of VEGF-B in obese compared with lean patients. PMID: 28798193
    3. Cardiac transgenic vascular endothelial growth factor-B overexpression failed to protect heart transplants from ischemia-reperfusion injury. PMID: 27588416
    4. renal VEGF-B expression correlates with the severity of Diabetic Kidney Disease. PMID: 28190774
    5. Data show that metformin treatment reduces serum vascular endothelial growth factor B (VEGF-B) levels and ameliorates insulin resistance. PMID: 26387747
    6. Frameshift mutations of VEGFB gene is associated with stomach and colorectal cancers. PMID: 25633991
    7. fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12. PMID: 25435370
    8. MMP9 may activate VEGF-B via PI3K/Akt signaling pathway. PMID: 25424698
    9. Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis. PMID: 24987705
    10. Low VEGFB and VEGFD gene expression is associated with early-stage non-small cell lung cancer. PMID: 24145997
    11. Our study suggested that VEGF-B was an angiogenesis factor in vitro and that ERK1/2 and p38-related signaling pathways were involved in these VEGF-B activities. PMID: 24374930
    12. VEGF-B has possible roles in cardiac protection, energy metabolism support, and neuroprotectin [review] PMID: 24987005
    13. High VEGF-B levels might correlate with the presence of hyperlipidemia and target organ damage in type 2 diabetic patients. PMID: 25001655
    14. High VEGFB expression is associated with bone marrow metastasis in neuroblastoma. PMID: 23553333
    15. VEGF-B might be an important ligand in the signalling between the tumor and preexisting blood vessels to ensure a functional blood supply for tumor survival. PMID: 23417498
    16. we report significant associations with overall survival and distant failure for certain VEGF(VEGF-B) family members. PMID: 23728940
    17. Data indicate that three miRs (miR-484, -642, and -217) were able to predict chemoresistance and vasculature of serous epithelial ovarian carcinomas through the regulation of the VEGFB and VEGFR2 pathways. PMID: 23697367
    18. Expression of VEGF-B genes in glioma cell lines U87 is significantly changed under hypoxia and ischemic conditions. PMID: 23350126
    19. In WT1 mutant cells, reduced VEGF(165)b was due to lack of WT1-mediated transcriptional repression of the splicing-factor kinase SRPK1 PMID: 22172722
    20. analysis of binding of vascular endothelial growth factor-B by VEGFR-1(D2) PMID: 20501651
    21. TIMP3 blocks the binding of VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis. PMID: 12652295
    22. Results describe the crystal structure of human vascular endothelial growth factor-B (VEGF-B) and present a predicted model for the association of VEGF-B with the second domain of its receptor, VEGFR-1. PMID: 16616187
    23. Basophils could play a role in angiogenesis and inflammation through the expression of several forms of VEGF-B and their receptors. PMID: 17082651
    24. VEGFB, and receptor were highly expressed in dysplastic neurons. IR in astroglial and balloon cells was observed for VEGFA and its receptors Double-labeling also showed expression of VEGFA, VEGFB and VEGFR-1 in cells of the microglia/macrophage lineage. PMID: 18317782
    25. VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. PMID: 18511699
    26. Increased VEGFB expression is associated with hepatocellular carcinoma PMID: 18537151
    27. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. PMID: 18757827
    28. The structural features of the 'highly ordered' interaction of the Fab fragment of the antibody (Fab-2H10) with VEGF-B, is presented. PMID: 18930733
    29. VEGF-B mRNA was not expressed either in normal urothelium or in bladder cancer. PMID: 19424629

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  • 亞細(xì)胞定位：
    Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
  • 蛋白家族：
    PDGF/VEGF growth factor family
  • 組織特異性：
    Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12681

    OMIM: 601398

    KEGG: hsa:7423

    STRING: 9606.ENSP00000311127

    UniGene: Hs.732095