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VP2 Antibody, HRP conjugated

  • 中文名稱：
    VP2兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA302471LB01CID
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) VP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    VP2
  • 別名：
    VP2Dual specificity protein phosphatase VP2 antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Chicken anemia virus
  • 免疫原：
    Recombinant Chicken anemia virus Dual specificity protein phosphatase VP2 protein (1-216AA)
  • 免疫原種屬：
    Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.
  • 基因功能參考文獻：
    1. The deletion of the C-terminal region of apoptin also impaired the replication of chicken anemia virus and attenuated its virulence in chickens. PMID: 28222746
    2. this study reports the use of apoptin and poly (I:C) combination as a novel strategy for cancer immunotherapy PMID: 27064544
    3. VP3-induced apoptosis, caspase-dependent intrinsic pathway plays an important role with the cleavage of poly (ADP-ribose) polymerase (PARP) PMID: 25809990
    4. Results show that The apoptosis induced by human adenovirus serotype 5 (AdHu5)-apoptin was independent of anti-apoptotic Bcl-2 and Bcl-xL proteins and the p53 pathway. PMID: 23812727
    5. In silico three-dimensional modeling of apoptin, molecular docking experiments between apoptin model and the known structure of Bcr-Abl, and the 3D structures of SH2 domains of CrkL and Bcr-Abl, were performed. PMID: 22253690
    6. These data demonstrate that Hsc70 is responsible for the down-regulation of Apoptin induced RelA/p65 gene expression. PMID: 21707973
    7. Apoptin induced the translocation of endogenous Hsc70 from the cytoplasm to the nucleus, and both were co-localized in the nucleus. PMID: 21565169
    8. Apoptin, expressed from the pseudotype baculovirus vector, has the potential to become a therapeutic agent for the treatment of solid tumors PMID: 19824041
    9. Apoptin, a protein from chicken anemia virus without an apparent cellular homologue, can induce apoptosis in mammalian cells. Its cytotoxicity is limited to transformed or tumor cells. PMID: 14765135
    10. Apoptin induces chromatin condensation when it is expressed in the nucleus and in the cytoplasm. PMID: 15965608
    11. role of c-Jun N-terminal kinase (JNK) in the apoptosis induced by apoptin gene in human lymphoma cell U937 PMID: 15989809
    12. Apoptin expression caused an increase in the tumor suppressor lipid ceramide, which regulates the cellular stress response PMID: 16887394
    13. apoptin kills tumor cells independently of PML and sumoylation, however, the interaction of apoptin with PML and small ubiquitin-like modifier (SUMO) proteins might be relevant for chicken anemia virus replication PMID: 16924230
    14. suggest that apoptin modulates ceramide/sphingolipid metabolism as part of its mechanism of action PMID: 16926120
    15. apoptin had an anti-neoplastic effect in vivo and in vitro in RSV-induced tumours PMID: 16963752
    16. T108 phosphorylation may only be required for the apoptotic activity mediated through the C-terminal apoptosis domain. PMID: 17223075
    17. PI3-K/Akt pathways have a dual role in both survival and cell death processes depending on the stimulus. PMID: 18021174
    18. Human peptidyl-prolyl isomerase-like 3 (Ppil3) is one of the Apoptin-associated proteins. PMID: 18474220
    19. C-terminus of apoptin (residues 74-121) is sufficient for tumor cell-enhanced nuclear targeting through phosphoinhibition of apoptin (74-121)-mediated nuclear export occurring exclusively in tumor cells. PMID: 18798550
    20. apoptin is necessary not only for DNA replication but also virus-like particle production of chicken anemia virus PMID: 19091368
    21. the pathway of apoptin-induced apoptosis and show that it essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation, resulting in the activation of the cyclin-dependent kinase CDK2 PMID: 19103742
    22. Apoptin specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Review. PMID: 19374922

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  • 蛋白家族：
    Gyrovirus protein VP2 family