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WSB1 Antibody, HRP conjugated

  • 中文名稱：
    WSB1兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA897589LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) WSB1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    WSB1
  • 別名：
    WSB1 antibody; SWIP1 antibody; WD repeat and SOCS box-containing protein 1 antibody; WSB-1 antibody; SOCS box-containing WD protein SWiP-1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human WD repeat and SOCS box-containing protein 1 protein (201-421AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.
  • 基因功能參考文獻(xiàn)：
    1. howed that miR-592 directly binds to the 3'-UTR of the WSB1 gene, thus disrupting hypoxia inducible factor-1alpha (HIF-1alpha) protein stabilization PMID: 27153552
    2. WSB1 is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier. PMID: 27958289
    3. WSB1 in glucose metabolism, and perhaps in mediating the Warburg effect in cancer cells by maintaining the function of HIF1. PMID: 27542736
    4. Our findings show how WSB1 regulates key steps of the metastatic cascade in hypoxia-driven osteosarcoma PMID: 26424695
    5. WSB1 up-regulates the expression of HIF-1alpha's target genes and promotes cancer invasion and metastasis through its effect on pVHL PMID: 26545811
    6. combination of WSB1(3) silencing together with WSB1 isoforms 1+2 silencing in NB cells showed reduced growth, enhanced apoptosis rate, and increased sensitivity to chemotherapeutic agents, specifically related to low expression of WSB1 PMID: 24441107
    7. HIF1 has a role in regulating WSB-1 expression, which promotes hypoxia-induced chemoresistance in hepatocellular carcinoma cells PMID: 23792163
    8. WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2). PMID: 15965468
    9. WSB1 shows strong correlations between expression level and copy number, and also enhances the prognostic prediction when combined with other current prognostic factors in neuroblastoma. PMID: 16804916
    10. the regulatory mechanisms by which HIPK2 is maintained at a low level, by WSB-1 in cells under normal conditions, and stabilized by genotoxic stresses. PMID: 18093972
    11. Data on WSB1 regulation support the hypothesis that activation of stress-response mechanisms helps cancer cells establishing metastases and suggest relevance to cancer development of other genes overexpressed in xenografts PMID: 18575577

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  • 數(shù)據(jù)庫鏈接：

    HGNC: 19221

    OMIM: 610091

    KEGG: hsa:26118

    STRING: 9606.ENSP00000262394

    UniGene: Hs.446017