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ZBED1 Antibody, Biotin conjugated

  • 中文名稱：
    ZBED1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA02715D0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ZBED1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZBED1
  • 別名：
    Ac like transposable element antibody; ALTE antibody; BED type zinc finger domain containing protein 1 antibody; DNA replication related element binding factor antibody; dREF homolog antibody; hDREF antibody; KIAA0785 antibody; Putative Ac like transposon antibody; Putative Ac-like transposable element antibody; TRAMP antibody; ZBED1 antibody; ZBED1_HUMAN antibody; Zinc finger BED domain-containing protein 1 antibody; Zinc finger BED type containing 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger BED domain-containing protein 1 protein (1-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins.; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
  • 基因功能參考文獻：
    1. These findings identify DREF as a novel adenovirus E1A C terminus binding partner and provide evidence supporting a role for DREF in viral replication. PMID: 25210186
    2. expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation PMID: 12663651
    3. self-association of hDREF via the hATC domain is necessary for its nuclear accumulation and DNA binding. PMID: 17209048
    4. hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of ribosomal protein genes PMID: 17220279
  • 亞細胞定位：
    Nucleus, PML body. Nucleus.; Nucleus, PML body.
  • 組織特異性：
    Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 447

    OMIM: 300178

    KEGG: hsa:9189

    STRING: 9606.ENSP00000370616

    UniGene: Hs.131452