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  4. ZBTB16 Antibody, Biotin conjugated

ZBTB16 Antibody, Biotin conjugated

  • 中文名稱：
    ZBTB16兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA21019D0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ZBTB16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZBTB16
  • 別名：
    AI467657 antibody; lu antibody; PLZF antibody; Promyelocytic leukemia zinc finger protein antibody; ZBT16_HUMAN antibody; ZBTB16 antibody; Zfp145 antibody; Zinc finger and BTB domain containing 16 antibody; zinc finger and BTB domain containing protein 16 antibody; Zinc finger and BTB domain-containing protein 16 antibody; Zinc finger protein 145 (Kruppel like expressed in promyelocytic leukemia) antibody; Zinc finger protein 145 antibody; Zinc finger protein PLZF antibody; Znf145 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger and BTB domain-containing protein 16 protein (126-420AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a transcriptional repressor. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能參考文獻：
    1. ZBTB16 is a sensitive and specific marker for yolk sac tumour (YST) and is diagnostically superior to AFP and glypican-3 in metastatic and extragonadal settings. PMID: 28581124
    2. Selected gene variants of the transcription factor ZBTB16 influence obesity-related parameters and serum lipid levels. PMID: 28948827
    3. ZBTB16 is a highly sensitive and specific marker for yolk sac tumors. PMID: 26916077
    4. Low ZBTB16 expression is associated with tongue squamous cell carcinoma. PMID: 28038473
    5. High PLZF expression is associated with acute myeloid leukemia. PMID: 28416638
    6. Emerging evidence shows that PLZF regulates the balance of self-renewal and differentiation in stem cells. PMID: 26676652
    7. integration of PLZF ChIP-Seq and RNA Pol II RNA-Seq datasets revealed that the early growth response 1 (EGR1) transcription factor is a PLZF target for which its level of expression must be reduced to enable progesterone dependent hESC decidualization PMID: 27035670
    8. NLRP7 is involved in Hydatidiform Molar Pregnancy (HYDM1) and interacts with the transcriptional repressor ZBTB16 PMID: 26121690
    9. These results support a prognostic value for loss of cytoplasmic PLZF expression in the stratification of non-small cell lung cancer and a possible role of cytoplasmic shift and down-regulation of PLZF in the pathogenesis of NSCLC. PMID: 26297253
    10. down-regulation of PLZF is an important molecular process for prostate tumor progression PMID: 25807461
    11. Down-regulation of PLZF in human hepatocellular carcinoma.PLZF expression was positively correlated with the alkaline phosphatase level in hepatocellular carcinoma patients. PMID: 25369784
    12. In dental follicle cells, a Runx2-independent differentiation mechanism exists that is regulated by ZBTB16. PMID: 24816988
    13. PLZF loss enhances castration-resistant prostate cancer tumor growth in a xenograft model. PMID: 25808865
    14. Data suggest that interleukin-32alpha (IL-32alpha) associates with leukemia zinc finger (PLZF) and protein kinase c epsilon (PKCvarepsilon), and then inhibits PLZF sumoylation, resulting in suppression of the transcriptional activity of PLZF. PMID: 25178676
    15. PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells. PMID: 25833398
    16. Authors found that PLZF mediates suppression of miR-146a to control increases of CXCR4 and TRAF6 protein levels in human primary CD4(+) T lymphocytes. PMID: 25705792
    17. Data indicate that normal ovarian tissues strongly expressed histone H1.5, whereas ovarian granulosa cell tumors (GCTs) weakly expressed this protein; in contrast, PLZF protein expression was not significantly different between both study groups. PMID: 25023763
    18. When comparing benign and malignant uterine tumors, statistically significant differences were found in staining patterns for PLZF. PMID: 24784718
    19. a PTEN/PLZF pathway and would shed new lights for developing therapeutic strategy of prostate cancer PMID: 24339862
    20. present study shows that ZBTB16 induced the expression of osteogenic differentiation markers independently of RUNX2. PMID: 24359167
    21. High cytoplasmic expression of PLZF is associated with capsular invasion and lymph node metastasis in thyroid neoplasms. PMID: 24990570
    22. The aim of this study was to analyse the contribution of constitutive (P)RR activity to its cellular effects and the relevance of prorenin glycosylation on its ligand activity. PMID: 24424509
    23. PLZF can directly repress transcription of CDKN1A encoding p21 PMID: 24821727
    24. overexpression of PLZF and exclusion of NK cells in dysplastic microenvironment are very early events in the stepwise sequence leading to CRC. PMID: 24348178
    25. TL1A, together with IL-12, IL-15 and IL-18, directly induces the production of IL-6 and TNF-alpha from PLZF leukocytes. PMID: 24416448
    26. Plzf was identified as a specific interacting protein of Znf179; the region containing the first two zinc fingers is critical for its interaction with Znf179. Cellular localization of Znf179 changed from cytoplasm to nucleus when Plzf was co-expressed. PMID: 24359566
    27. PLZF may have a role in the pathway of drug resistance associated with a TRAV1-2-TRAJ33 TCR-alpha rearrangement in peripheral T-cell lymphomas PMID: 24764561
    28. This study showed that reduced expression of PLZF was found to be common in nonsmall cell lung cancer; PLZF down-regulation was partially correlated with hypermethylation in the promoter region. PMID: 23804241
    29. RARalpha-PLZF fusion protein inhibits myeloid cell differentiation through interactions with C/EBPalpha tethered to DNA in acute promyelocytic leukemia. PMID: 23898169
    30. Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors. PMID: 23416030
    31. The p65 PLZF isoform is crucial to maintain colorectal cancer cell growth, adhesion and survival, and must occur independently of the traditionally viewed transcriptional role of PLZF in the course of these biological processes. PMID: 23280881
    32. Our findings identify a previously unknown pathway of regulation of innate-like T-cell homeostasis depending on XIAP and PLZF. PMID: 23223428
    33. Expression of the promyelocytic leukemia zinc-finger in T-lymphoblastic lymphoma and leukemia has strong implications for their cellular origin and greater association with initial bone marrow involvement. PMID: 22555178
    34. Far infrared rays induce the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in HUVECs. PMID: 22292015
    35. PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs. PMID: 21915328
    36. Small interfering RNA-mediated gene silencing of ZNF145 slowed down chondrogenesis, whereas overexpression of ZNF145 enhanced chondrogenesis. PMID: 21547890
    37. Although PLZF is known to direct the effector program of natural killer (NK)T cells, this study shows that CD1d naive-like cells express it at a significantly lower amount than NKT cells. PMID: 21632718
    38. CUX1 interacts in vivo with multiple DNA-binding sites in the 5'-UTR and promoter of the PLZF gene in colorectal cancer cells PMID: 20945532
    39. Data indicate that deletions of PLZF are a common occurrence in MM and that downregulation of PLZF may contribute to MM pathogenesis by promoting cell survival. PMID: 20010871
    40. a substantial number of fetal thymocytes and splenocytes express PLZF and acquire innate characteristics during their development in humans. PMID: 20038602
    41. Data show that PLZF-RARalpha binds to a region of the c-MYC promoter, suggesting that PLZF-RARalpha may act as a dominant-negative version of PLZF by affecting the regulation of shared targets. PMID: 19855079
    42. two critical hits for promyelocytic leukemia PMID: 11106752
    43. PLZF/RARalpha also binds the HD-NCR through the PLZF, which seems to be crucial for the t-RA resistance of t(11;17) APL patients PMID: 11920278
    44. can interact with GATA-2 and can modify GATA-2 transactivation capacity PMID: 11964310
    45. evidence of a functional interaction between the promyelocytic leukemia zinc finger protein (PLZF) and DRAL/FHL2 PMID: 12145280
    46. PLZF plays a significant stimulatory role in megakaryocytic development, seemingly mediated in part by induction of TpoR expression at transcriptional level. PMID: 12242665
    47. Hoxb2 is a direct target for regulation by PLZF in the developing CNS and suggest that deregulation of Hox gene expression may contribute to APL pathogenesis. PMID: 12802276
    48. gene expression regulation in human endometrial stromal cells and myometrial smooth muscle cells PMID: 12970399
    49. PLZF expression maintains a cell in a quiescent state by repressing c-myc expression and preventing cell cycle progression. PMID: 14645547
    50. An inactive mutant of PLZF abolishes expression of p85 alpha PI3K followed by enhanced p70(S6) kinase. PMID: 14657020

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  • 相關(guān)疾?。?/div>
    Skeletal defects, genital hypoplasia, and mental retardation (SGYMR)
  • 亞細胞定位：
    Nucleus. Nucleus, nuclear body.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12930

    OMIM: 176797

    KEGG: hsa:7704

    STRING: 9606.ENSP00000338157

    UniGene: Hs.591945