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eta Antibody

  • 中文名稱：
    eta兔多克隆抗體
  • 貨號：
    CSB-PA319297XA01FQE
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: eta antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39.9 kDa
      Observed band size: 48 kDa
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    eta
  • 別名：
    Exotoxin A (ETA) (EC 2.4.2.36) (NAD(+)--diphthamide ADP-ribosyltransferase) (PE) eta PA1148
  • 反應(yīng)種屬：
    Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
  • 免疫原：
    Recombinant Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) TOXA protein (413-638aa)
  • 免疫原種屬：
    Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Protein G
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.
  • 基因功能參考文獻(xiàn)：
    1. Our results show that the chimeric EGFETA toxin is extremely effective against EGFRpositive cancers and raises the potential to further develop this chimera for use in targeting EGFRpositive tumours resistant to monoclonal antibodies. PMID: 30226622
    2. Studied the presence of virulence genes (B-type flagellin [fliC], exotoxin A [toxA] and phzS) using molecular typing among isolates of Pseudomonas aeruginosa cultured from specimens from diabetic foot. Found fliC, toxA and phzS genes can play important roles in tissue penetration, tissue damage and survival. PMID: 29078729
    3. Data indicate that anti-EpCAM fusion toxin for tumor targeting by click PEGylation suggest new perspectives for effective cancer-related therapy. PMID: 24184633
    4. Use of the antibodies produced for testing toxigenicity of P. aeruginosa strains as well as detection of anatoxin in the technological process of production of prophylaxis preparations based on exotoxin A is expected. PMID: 24738291
    5. The highest level was observed for IL-1 and IL-6 after administration of recombinant proteins OprL, OprF, OprF-1, aTox. PMID: 24605680
    6. ATF-7 and ZIP-2 transcription factors are required for preventing ToxA-mediated lethality. PMID: 22520464
    7. These results indicated that exotoxin A acts as a virulence factor in Bombyx mori and that other virulence factor(s) are involved during the late stages of infection. PMID: 21945328
    8. When combined with IL-13Ralpha2 DNA cancer vaccine, Pseudomonas aeruginosa exotoxin A mediates synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models. PMID: 22013118
    9. Norepinephrine represses the expression of toxA and the siderophore genes. PMID: 19686346

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  • 數(shù)據(jù)庫鏈接：

    KEGG: pae:PA1148

    STRING: 208964.PA1148