lepA Antibody, Biotin conjugated
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中文名稱:lepA兔多克隆抗體, Biotin偶聯(lián)
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貨號(hào):CSB-PA350834LD01ENV
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Escherichia coli lepA Polyclonal antibody
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Uniprot No.:
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基因名:lepA
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別名:lepA antibody; b2569 antibody; JW2553Elongation factor 4 antibody; EF-4 antibody; EC 3.6.5.n1 antibody; Ribosomal back-translocase LepA antibody
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宿主:Rabbit
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反應(yīng)種屬:Escherichia coli
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免疫原:Recombinant Escherichia coli Elongation factor 4 protein (1-599AA)
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免疫原種屬:Escherichia coli
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標(biāo)記方式:Biotin
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克隆類(lèi)型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA
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Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
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基因功能參考文獻(xiàn):
- The last 44 C-terminal amino acids of EF4 form a sub-domain within the C-terminal domain that is important for GTP-dependent function on the ribosome. PMID: 25712150
- Thus, EF4 has two opposing functions-at low-to-moderate levels of stress, the protein is protective by allowing stress-paused translation to resume; at high-levels of stress, EF4 helps bacteria self-destruct. PMID: 25491353
- (review) EF4 triggers back-translocation of the elongating ribosome, causing the translation machinery to move one codon backwards along the mRNA. PMID: 23662805
- Elevated intracellular Mg(2+) concentrations or low temperature inhibit protein synthesis, probably because of formation of aberrant elongating ribosomal states. We suggest that EF4 binds to these stuck ribosomes and remobilizes them PMID: 21300907
- EF4-dependent back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex via a four-step kinetic scheme (i.e., POST-->I(1)-->I(2)-->I(3)-->PRE PMID: 20045415
- LepA protein, present in all bacteria and mitochondria, is a third elongation factor required for accurate and efficient protein synthesis. PMID: 17110332
- The crystal structure of LepA from Escherichia coli at 2.8-A resolution, was determined. PMID: 18362332
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亞細(xì)胞定位:Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族:TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, LepA subfamily
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數(shù)據(jù)庫(kù)鏈接:
KEGG: ecj:JW2553
STRING: 316385.ECDH10B_2737
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