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tbxta Antibody

  • 中文名稱：
    tbxta Antibody
  • 貨號(hào)：
    CSB-PA237357XA01DIL
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:tbxta Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 46.5 kDa
      Observed band size: 44 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) tbxta Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    tbxta
  • 別名：
    Brachyury protein homolog A (No tail protein A) (No tail protein) (Protein T homolog A) (T-box protein ZfT) (Zf-T) ntla ntl t
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 免疫原：
    Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) tbxta protein (44-212aa)
  • 免疫原種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail formation. Required for the morphogenesis of Kupffer's vesicle and regulates left-right asymmetry.
  • 基因功能參考文獻(xiàn)：
    1. Ntla and Spt do not differentially regulate medial floor plate (MPF) induction along the anterior-posterior axis; rather, the T-box genes act redundantly within margin derived cells to promote the posterior extension of MFP progenitors. PMID: 25781211
    2. observed normal cardiac convergence in spt(-/-) and ntl(-/-) embryos implying that these novel roles of spt and ntl in PGP migration cannot be explained simply by generalised effects on midline convergence PMID: 23860396
    3. As a proof of principle, it has dynamically profiled No tail a (Ntla)-dependent genes at different stages of axial mesoderm development in zebrafish, discovering discrete sets of transcripts. PMID: 22286130
    4. embryonic mesodermal progenitors uniquely establish their own niche--with Brachyury being essential for creating a domain of high Wnt and low RA signaling--rather than having a niche created by separate support cells. PMID: 21159819
    5. Data demonstrate that the nodal-independent regulation of ntl is essential for tail formation in zebrafish. PMID: 20215349
    6. ntl function is required to repress medial floor plate and promote notochord fate in cells of the wild-type notochord domain and spt and ntl together are required non cell-autonomously for medial floor plate formation. PMID: 12091302
    7. intronless ntl gene, ctl has a physiological function in zebrafish PMID: 12804607
    8. Interplay between FGF, one-eyed pinhead (zoep), and T-box transcription factors spt and ntl during zebrafish posterior development. PMID: 14651930
    9. no tail gene (ntl), a key gene participating in the formation of normal tail, was used as a target for ribonuclease (RNase) P-mediated gene disruption in zebrafish in vivo. PMID: 17294249
    10. investigate whether loss of Brachyury/Notail or Tbx16/Spadetail disrupts the balance of Nodal ligands (Southpaw) and antagonists (Charon) around Kupffers Vesicle PMID: 17654709
    11. Ntl is necessary for KV lumen formation. PMID: 17765888
    12. the endoplasmic reticulum Ca(2+) pump has a role in expression of no tail (ntl) and left-right dynein related (lrdr) in the dorsal forerunner cells during gastrulation PMID: 18359204
    13. Regulation of canonical Wnt signaling by ntl is essential for posterior mesoderm formation. PMID: 18606146
    14. Ntl regulates a downstream network of other transcription factors and identify an in vivo Ntl binding site that resembles the consensus T-box binding site (TBS) previously identified by in vitro studies. PMID: 19225104

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    First expressed at the dorsal side of the blastula embryo. Expressed in the germ ring, shield and chordamesoderm during gastrulation and is restricted to the notochord and tailbud during somitogenesis (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dre:30399

    STRING: 7955.ENSDARP00000005351

    UniGene: Dr.1468