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  4. LDHC Recombinant Monoclonal Antibody

LDHC Recombinant Monoclonal Antibody

  • 中文名稱：
    LDHC重組抗體
  • 貨號：
    CSB-RA886298A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing Hela cells stained with CSB-RA886298A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The generation of the LDHC recombinant monoclonal antibody involves a genetic engineering process that includes cloning and expression of the gene responsible for the LDHC monoclonal antibody. To generate the LDHC monoclonal antibody, a synthesized peptide derived from human LDHC protein was used as the immunogen. The LDHC recombinant monoclonal antibody was purified using affinity chromatography to ensure high purity. It specifically recognizes and binds to the human MAS1L protein. The quality and specificity of the LDHC recombinant monoclonal antibody have been confirmed through two applications ELISA and FC.

    LDHC is an enzyme that plays a crucial role in the anaerobic metabolism of glucose. It catalyzes the reversible conversion of pyruvate to lactate, producing NAD+ from NADH. This process is important in energy production during periods of high-intensity exercise when oxygen availability is limited. LDHC is predominantly expressed in the testis, where it is essential for the process of spermatogenesis. However, it is also expressed in other tissues, such as muscle and brain, where it may have other functions beyond energy metabolism. Mutations in the LDHC gene have been associated with male infertility.

  • Uniprot No.：
  • 基因名：
  • 別名：
    L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X), LDHC, LDH3 LDHX
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human LDHC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Possible role in sperm motility.
  • 基因功能參考文獻(xiàn)：
    1. Lactate dehydrogenase C may act as a novel biomarker for renal cell carcinoma progression and a potential therapeutic target for the treatment of renal cell carcinoma. PMID: 28351304
    2. three uniquely identified proteins (CDK6 , galectin-3-binding protein and LDH C) were found, which show tight connection with prostate cancer and presence of all of them was previously linked to certain aspects of prostate cancer PMID: 26503549
    3. Down-regulated LDH-C4 expression is significantly correlated with lowered enzyme activity in human spermatozoa. PMID: 25795631
    4. This is the first report to show a positive correlation between LDH-3 and hemolytic parameters in sickle cell anemia. PMID: 26069337
    5. LDH3 was increased in essential thrombocythemia. This isoenzymatic pattern could be expression of a metabolic adaptation. PMID: 17178662
    6. LDH3 is a supporting diagnostic marker in cases of chronic tuberculosis. PMID: 17935709
    7. hLdhc expression in cancer cells was regulated by transcription factor Sp1 and CREB and promoter CGI methylation PMID: 18930904

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    LDH/MDH superfamily, LDH family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6544

    OMIM: 150150

    KEGG: hsa:3948

    STRING: 9606.ENSP00000280704

    UniGene: Hs.654377