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  4. FABP4 Recombinant Monoclonal Antibody

FABP4 Recombinant Monoclonal Antibody

  • 中文名稱：
    FABP4重組抗體
  • 貨號：
    CSB-RA007945A0HU
  • 規(guī)格：
    ￥1320
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    This is a recombinant monoclonal antibody against FABP4. It is matched isotype control by rabbit IgG. The cloning of the human FABP4 DNA gene into the vector and subsequent transfection into the cell line for in vitro expression lead to the production of this FABP4 antibody. This FABP4 antibody can recognize the human FABP4 protein. It has been purified using affinity-chromatography and been tested for use in ELISA application.

    FABP4, also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages. It plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation. Studies have identified that FABP4 is directly associated with cardiac alterations such as left ventricular hypertrophy (LVH) and both systolic and diastolic cardiac dysfunction.

  • Uniprot No.：
  • 基因名：
  • 別名：
    3T3-L1 lipid-binding protein antibody; 422/aP2 antibody; A-FABP antibody; adipocyte antibody; Adipocyte lipid binding protein antibody; Adipocyte lipid-binding protein antibody; Adipocyte protein AP2 antibody; Adipocyte-type fatty acid-binding protein antibody; AFABP antibody; ALBP antibody; ALBP/Ap2 antibody; aP2 antibody; Epididymis secretory protein Li 104 antibody; FABP antibody; FABP4 antibody; FABP4_HUMAN antibody; Fatty acid binding protein 4 adipocyte antibody; Fatty acid binding protein 4 antibody; Fatty acid binding protein adipocyte antibody; Fatty acid-binding protein 4 antibody; Fatty acid-binding protein antibody; HEL S 104 antibody; Lbpl antibody; Myelin P2 protein homolog antibody; P15 antibody; P2 adipocyte protein antibody; Protein 422 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human FABP4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1H4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
  • 基因功能參考文獻：
    1. FABP4 shows potential as a novel biomarker for diabetic retinopathy prediction in Chinese patients with type 2 diabetes (T2DM), and strict glycemic control and more frequent retinal examination should be highlighted for T2DM patients with the highest quartile range of FABP4. PMID: 29305311
    2. association between serum FABP4 concentrations and sarcopenia in chronic hemodialysis patients PMID: 29935964
    3. intermittent high glucose potentiates A-FABP activation and inflammatory responses via TLR4/p-JNK signaling in THP-1 cells PMID: 29850615
    4. High serum A-FABP concentration is associated with peripheral arterial disease in women, but not men, with type 2 diabetes mellitus. PMID: 28303680
    5. FABP4 from adipocytes mediate adipocyte-cholangiocarcinoma interactions that are crucial for the invasion, migration and epithelial-mesenchymal transition of cholangiocarcinoma cells PMID: 29237483
    6. Compared with the low arterial stiffness group, the high arterial stiffness group had higher values for age, systolic blood pressure, pulse pressure, duration of kidney transplantation and serum A-FABP PMID: 28660445
    7. Blood FABP4 is a biomarker for metabolic syndrome and cardiovascular disease independently of HIV status and antiretroviral therapy. PMID: 29304747
    8. Increased FABP4 blood level is a biomarker of lead exposure in women. PMID: 29264639
    9. ubiquitylation destabilizes the fold of two proteins, FKBP12 and FABP4 PMID: 27991582
    10. Compared to control group, breast cancer patients show higher FABP4 and FABP5 blood levels. Our data suggest that, particularly, circulating FABP4 levels could be considered a new independent breast cancer biomarker. Our work translates basic science data to clinic linking the relationship between adipose tissue and lipid metabolism to breast cancer. PMID: 28701570
    11. findings reveal a pro-angiogenic role of FABP4 in first trimester placental trophoblast cells and its regulation may have impact in placental physiology. PMID: 28620819
    12. A-FABP concentration was an independent predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention. PMID: 29017449
    13. Ectopic expression and secretion of FABP4 in vascular endothelial cells contribute to neointima formation after vascular injury. PMID: 28903937
    14. Elevated A-FABP concentration could be a predictor for MetS and arterial stiffness in hypertensive patients PMID: 28860092
    15. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. PMID: 27270834
    16. Increased second trimester plasma FABP4 independently predicted GH/PE in GDM patients PMID: 29394285
    17. our research demonstrated that high FABP3 or FABP4 expression had strong prognostic value for overall survival in non-small cell lung cancer PMID: 27323829
    18. The distribution of genotype frequencies in the assessed women (PON1 Q192R polymorphism) was QQ = 20%, QR = 48% and RR = 32%. Significantly higher serum FABP4 levels were found in women with genotype QR/RR (20.6 +/- 2.20 ng/mL), when compared with the levels found in the QQ group (12.8 +/- 1.70 ng/mL) (p = .004). PMID: 27712128
    19. serum A-FABP levels were increased significantly in normoglycemic individuals with a first-degree family history of diabetes; the use of serum A-FABP as a biomarker in the first-degree relatives of patients with diabetes may result in overestimation of the risk of obesity-induced metabolic disease and cardiovascular disease PMID: 27534843
    20. Findings in the dorsolateral prefrontal cortex in schizophrenia provide evidence of altered proteins involved in synaptic function (FABP4), cytoarchitecture organization (NEFH), and circadian molecular clock signaling (CSNK1E), which may be contributing to the cognitive and/or negative symptoms in this disorder. FABP4, CSNK1E and NEFH could become potentially useful biomarkers for schizophrenia. PMID: 27236410
    21. Circulating levels of AFABP and EFABP are not decreased in Lipodystrophy despite adipose tissue loss in contrast to other adipokines including leptin and adiponectin. PMID: 28088613
    22. Taken together, PPAR gamma and FABP4 gene expression levels in PBMCs [peripheral blood mononuclear cells] may be indicators of metabolic factors and body composition components. PMID: 27563749
    23. eFABP4 induces ER stress and potentiates the effect of linoleic acid in HepG2 cells, suggesting that FABP4 could be a link between obesity-associated metabolic abnormalities and hepatic insulin resistance mechanisms PMID: 27155388
    24. Increased second-trimester FABP4 independently predicted pre-eclampsia in women with type 1 diabete and significantly improved reclassification and discrimination. PMID: 27630211
    25. High levels of FABP4 are significantly related to stroke risk and severity, independent from other traditional and emerging risk factors, suggesting that they may play a role in stroke pathogenesis. PMID: 28781090
    26. We found that serum FABP4 concentration were associated with insulin resistance and secretion in type 2 diabetes mellitus. This suggests that FABP4 may play an important role in glucose homeostasis. PMID: 28654680
    27. High FABP4 expression is associated with ovarian cancer. PMID: 27568980
    28. AFABP levels were higher in neonates compared with adults. Preterm infants had higher AFABP levels compared with full-term infants. Among full-term infants, AFABP levels in SGA infants were lower, compared with appropriate for gestational age and large for gestational age infants. PMID: 28324040
    29. Exogenous FABP4 plays a key role in tumor proliferation and activates the expression of fatty acid transport proteins in MCF-7 breast cancer cells. PMID: 27061264
    30. High FABP4 expression is associated with Acute Monocytic Leukemia. PMID: 28108519
    31. FABP4 over-expression in cardiomyocytes can aggravate the development of cardiac hypertrophy through the activation of ERK signal pathway. PMID: 27294862
    32. Results show that serum FABP4 levels were significantly increased in patients with psoriasis. PMID: 27864793
    33. secreted FABP4 and FABP5 from adipocytes as adipokines differentially affect transcriptional and metabolic regulation in ADSC near adipocytes PMID: 27936164
    34. FABP4 locally produced by epicardial/perivascular fat and macrophages in vascular plaques contributes to the development of coronary atherosclerosis. PMID: 27013610
    35. Elevated levels of FABP4 are associated with higher cardiovascular mortality among men with type 2 diabetes. PMID: 27609367
    36. These genes should be at the downstream of signal pathways and be regulated by the 23 genes identified before. Our findings may provide a unique new model for studying the molecular control of cattle cross-talk between adipose and skeletal muscle. PMID: 27856250
    37. higher serum A-FABP level is positively associated with MetS in type 2 DM patients PMID: 28042581
    38. FABP4 level was independently associated with gender, adiposity, renal dysfunction, and levels of cholesterol. PMID: 27241838
    39. FABP4 DNA hypomethylation induced by Hcy may be involved in the overexpression of FABP4, thereby inducing cholesterol accumulation in macrophages. PMID: 27221153
    40. Study found that the fasting insulin and age-adjusted AFABP concentrations were significantly higher in the gestational diabetes mellitus group of women compared with the normal glucose tolerance participants in the mid- and late stages of pregnancy. PMID: 27181269
    41. mTOR/FABP4 signaling pathway directly regulates the proliferation of endothelial cells in hemangioma. Rapamycin and inhibitors of FABP4 have therapeutic potential for treating infantile hemangiomas. PMID: 27914823
    42. Results suggested that the expression of a lipid metabolism-related gene and an important SNP in the 3'-UTR of FABP4 are associated with TNBC prognosis. PMID: 26959740
    43. In multiple linear regression stepwise analysis, BMI, HbA1C, and HOMA-IR were significantly independent determinants for A-FABP. BMI, HbA1C, and HOMA-IR are independently associated with A-FABP in obese subjects with newly diagnosed type 2 diabetes. A-FABP may be related to insulin resistance and inflammation in type 2 diabetes and concomitant obesity. PMID: 27819006
    44. The increase in placental FABP4 expression in preeclampsia may affect the function of trophoblast, and this increase may have a role in the pathogenesis of preeclampsia. PMID: 26992681
    45. our findings set up a novel mechanism for FABP4, adipsin and adiponectin through gut microbiota mediating expression in gut Paneth cells. PMID: 26687459
    46. results underline a gender difference in FABP4 secretion in stable COPD patients. PMID: 26823558
    47. Increased FABP4 level showed increased risk for reduced lung function in subjects with normal ventilatory function. PMID: 26887419
    48. High FABP expression is associated with Sepsis. PMID: 27089280
    49. Serum irisin might exert antagonistic effects on FABP4 in the middle-aged Chinese population. PMID: 26752184
    50. Urinary FABP4 level is independently correlated with level of albuminuria and possibly predicts yearly decline of estimated glomerular filtration rate. Urinary FABP4 would be a novel biomarker of glomerular damage. PMID: 25506691

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3559

    OMIM: 600434

    KEGG: hsa:2167

    STRING: 9606.ENSP00000256104

    UniGene: Hs.391561