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  4. Recombinant Avian infectious bursal disease virus RNA-directed RNA polymerase (VP1), partial

Recombinant Avian infectious bursal disease virus RNA-directed RNA polymerase (VP1), partial

  • 中文名稱：
    Recombinant Avian infectious bursal disease virus RNA-directed RNA polymerase(VP1) ,partial,Yeast
  • 貨號：
    CSB-YP769172AGAO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Avian infectious bursal disease virus RNA-directed RNA polymerase(VP1) ,partial,Yeast
  • 貨號：
    CSB-EP769172AGAO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Avian infectious bursal disease virus RNA-directed RNA polymerase(VP1) ,partial,Yeast
  • 貨號：
    CSB-EP769172AGAO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Avian infectious bursal disease virus RNA-directed RNA polymerase(VP1) ,partial,Yeast
  • 貨號：
    CSB-BP769172AGAO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Avian infectious bursal disease virus RNA-directed RNA polymerase(VP1) ,partial,Yeast
  • 貨號：
    CSB-MP769172AGAO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    VP1
  • Uniprot No.：
  • 別名：
    VP1; RNA-directed RNA polymerase; RDRP; EC 2.7.7.48; Protein VP1
  • 種屬：
    Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities.
  • 基因功能參考文獻(xiàn)：
    1. Different domains of RNA-dependent RNA polymerase VP1 (VP1) were shown to have different effects on viral replication, virulence as well as the polymerase activity o infectious bursal disease virus (IBDV). PMID: 29948899
    2. study reports that interaction of the host eIF4AII with Infectious bursal disease virus (IBDV) VP1 inhibits the RNA polymerase activity of IBDV to reduce its replication in host cells PMID: 27908831
    3. The amino acid triplet located at positions 145/146/147 of VP1 was found highly conserved and their important role in the pathogenicity of infectious bursal disease virus was confirmed in this study. PMID: 24431234
    4. Authors identified a Valine to Isoleucine substitution at amino acid position 4 (V4I) of VP1 that attenuates viral pathogenicity and reduces viral replication in SPF chickens but increases viral replication in chicken embryo fibroblast cells. PMID: 23537958
    5. Unusual cobalt dependence of this enyme may be linked to the permuted organization of the motif. PMID: 17872536
    6. Birnavirus VP1 self-guanylylation is catalyzed by an active site that does not completely overlap with or may even be different from that for nucleotide polymerization within the same molecule. PMID: 19801157

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  • 亞細(xì)胞定位：
    Virion.
  • 數(shù)據(jù)庫鏈接：

    KEGG: vg:956510