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  4. Recombinant Chicken Hypoxia-inducible factor 1-alpha (HIF1A), partial

Recombinant Chicken Hypoxia-inducible factor 1-alpha (HIF1A), partial

  • 中文名稱：
    雞HIF1A重組蛋白
  • 貨號(hào)：
    CSB-YP896655CH
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    雞HIF1A重組蛋白
  • 貨號(hào)：
    CSB-EP896655CH
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    雞HIF1A重組蛋白
  • 貨號(hào)：
    CSB-EP896655CH-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    雞HIF1A重組蛋白
  • 貨號(hào)：
    CSB-BP896655CH
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    雞HIF1A重組蛋白
  • 貨號(hào)：
    CSB-MP896655CH
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    HIF1AHypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha
  • 種屬：
    Gallus gallus (Chicken)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
  • 基因功能參考文獻(xiàn)：
    1. HIF-1alpha, -2alpha, and -3alpha expressions in the tibial growth plate of Tibetan chickens were upregulated by hypoxia and the change was more significant than in Arbor Acres chickens. PMID: 28693310
    2. FK228 (HIF-1alpha inhibitor) significantly (P less than 0.05) down- regulated the mRNA and protein levels of HIF-1alpha and Hsp90, restored the size of growth plate and diminished lameness. In conclusion, HIF-1alpha and Hsp90 play an important role in the formation of avascular growth plate and there is a direct relationship between HIF-1alpha and Hsp90 for the progression of TD pathogenesis PMID: 29504370
    3. Altering HIF-1alpha through 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure affects coronary vessel development. PMID: 23264063
    4. These findings hinted that HIF-1alpha might be associated with the development of ascites syndrome induced by excess salt in drinking water in broiler chickens. PMID: 23873551
    5. Epicardial HIF signaling regulates vascular precursor cell invasion into the myocardium PMID: 23384563
    6. HIF-1alpha induction during hypoxic preconditioning is necessary to obtain enhanced HIF-1alpha accumulation and to develop tolerance against a subsequent hypoxic injury. PMID: 21953610
    7. Data suggest that developing coronary vessels may be subject to a level of regulation that is dependent on differential oxygen levels within cardiac tissues and subsequent HIF-1alpha regulation of gene expression. PMID: 19777592
    8. Results showed that HIF-1alpha mRNA displayed tissue specific differential expression, with the highest in the brain PMID: 17284428
    9. This study found that tissue hypoxia is likely a normal component of embryonic development in the chicken based on the upregulation of hypoxia response genes. PMID: 17954589
    10. Hypoxia signaling through HIF-1 and VEGF provides an autocrine survival signal in the developing cardiac output flow tract[OFT] and that perturbation in this pathway causes OFT defects that model congenital human conotruncal heart defects. PMID: 18467628

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Nucleus speckle.
  • 數(shù)據(jù)庫(kù)鏈接：