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Recombinant Cricetulus griseus Peroxiredoxin-1 (PRDX1)

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  • 中文名稱：
    Recombinant Cricetulus griseus Peroxiredoxin-1(PRDX1)
  • 貨號：
    CSB-EP872876DXU
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP872876DXU could indicate that this peptide derived from E.coli-expressed Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) PRDX1.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP872876DXU could indicate that this peptide derived from E.coli-expressed Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) PRDX1.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    PRDX1; TDPX2Peroxiredoxin-1; EC 1.11.1.15; Thioredoxin peroxidase 2; TPX-2
  • 種屬：
    Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    26.1kDa
  • 表達(dá)區(qū)域：
    2-199aa
  • 氨基酸序列
    SSGNAKIGYPAPNFKATAVMPDGQFRDICLSEYRGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEILRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    A DNA corresponding to 2-199aa of Cricetulus griseus Peroxiredoxin-1 (PRDX1) was fused with an N-terminal 6xHis-tag and then expressed in E.coli. The resulting protein is a Recombinant Full-length pf Mature Cricetulus griseus PRDX1. This PRDX1 protein underwent the validation of SDS-PAGE and LC-MS/MS Analyses. The purity of the protein is over 90%. Its predicted molecular weight is 26.1 kDa. In addition to being an immunogen for antibody synthesis, this recombinant PRDX1 may also find uses in the studies of PRDX1-involved cell biology. In-stock PRDX1 proteins are available.

    PRDX1 belongs to the superfamily of small non-seleno peroxidases and exerts a peroxide-scavenging function. In addition, PRDX1 also orchestrates redox-regulated signaling in a ROS dose-dependent manner through the oxidation status of its peroxidative cysteine Cys52. The peroxidative cysteine Cys52 of PRDX1 acts as a sensor in ROS signaling. PRDX1 promotes both MKP-1 and MKP-5 activity under normal ROS homeostasis. Upon ROS increasing, PRDX1 becomes over-oxidized and less available to bind to MKP-1, eliciting MKP-1 oxidation-induced oligomerization and inactivity toward p38MAPKα, thus facilitating apoptosis.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peroxiredoxin family, AhpC/Prx1 subfamily
  • 數(shù)據(jù)庫鏈接：