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  4. Recombinant Danio rerio Two pore calcium channel protein 2 (tpcn2), partial

Recombinant Danio rerio Two pore calcium channel protein 2 (tpcn2), partial

  • 中文名稱(chēng)：
    斑馬魚(yú)tpcn2重組蛋白
  • 貨號(hào)：
    CSB-YP024095DIL
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    斑馬魚(yú)tpcn2重組蛋白
  • 貨號(hào)：
    CSB-EP024095DIL
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    斑馬魚(yú)tpcn2重組蛋白
  • 貨號(hào)：
    CSB-EP024095DIL-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    斑馬魚(yú)tpcn2重組蛋白
  • 貨號(hào)：
    CSB-BP024095DIL
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    斑馬魚(yú)tpcn2重組蛋白
  • 貨號(hào)：
    CSB-MP024095DIL
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    tpcn2
  • Uniprot No.：
  • 別名：
    tpcn2; tpc2; zgc:152898; Two pore calcium channel protein 2; Voltage-dependent calcium channel protein TPC2
  • 種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest a novel function for NAADP/TPC2-mediated Ca(2+) signaling in the development, coordination, and maturation of the spinal network in zebrafish embryos. PMID: 29577882
    2. localized calcium (Ca(2+)) release via TPC2 might trigger the generation of more global Ca(2+) release from the sarcoplasmic reticulum via Ca(2+)-induced Ca(2+) release. PMID: 28390800
    3. TPC2-mediated Ca(2+) release from lysosomes may act upstream from RyR- and IP 3R-mediated Ca(2+) release, suggesting that the former might initiate the SR-mediated Ca(2+)-induced-Ca(2+)-release essential for SMC myogenesis and function. PMID: 26679948
  • 亞細(xì)胞定位：
    Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family, Two pore calcium channel subfamily
  • 數(shù)據(jù)庫(kù)鏈接：