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  4. Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1 (Chd1), partial

Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1 (Chd1), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1(Chd1) ,partial,Yeast
  • 貨號(hào)：
    CSB-YP762562DLU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1(Chd1) ,partial,Yeast
  • 貨號(hào)：
    CSB-EP762562DLU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1(Chd1) ,partial,Yeast
  • 貨號(hào)：
    CSB-EP762562DLU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1(Chd1) ,partial,Yeast
  • 貨號(hào)：
    CSB-BP762562DLU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1(Chd1) ,partial,Yeast
  • 貨號(hào)：
    CSB-MP762562DLU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Chd1
  • Uniprot No.：
  • 別名：
    Chd1; CG3733; Chromodomain-helicase-DNA-binding protein 1; CHD-1; EC 3.6.4.12; ATP-dependent helicase Chd1
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome. Involved in assembly of active chromatin. Required for maintaining open chromatin and pluripotency in embryonic stem cells and is important for wing development and fertility. Is essential for the incorporation of histone H3.3 and assembly of paternal chromatin. Required for replication-independent nucleosome assembly in the decondensing male pronucleus.
  • 基因功能參考文獻(xiàn)：
    1. An effect of Chd1 null mutation can be increased by deficiency of one of the genes, encoding variant histone H3.3, His 3.3 B, suggesting that the role of CHD1 in the control of male X chromosome organization can be mediated by CHD1 activity in H3.3 histone deposition and exchange. PMID: 30191695
    2. The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2. PMID: 23533627
    3. Intestinal resistance against infection by P. aeruginosa is linked to maintaining proper balance of gut-microbe interactions and the chromatin remodeler CHD1 is involved in regulating this aspect. PMID: 22912810
    4. our results emphasize a role for Chd1 in histone replacement in both budding yeast and Drosophila melanogaster, and surprisingly they show that the major effects of Chd1 on turnover occur at the 3' ends of genes. PMID: 22807688
    5. results suggest a role for CHD1 in the assembly of active chromatin and a function of ACF in the assembly of repressive chromatin PMID: 15643425
    6. findings establish CHD1 as a major factor in replacement histone metabolism in the nucleus and reveal a critical role for CHD1 in the earliest developmental instances of genome-scale, replication-independent nucleosome assembly. PMID: 17717186
    7. These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function. PMID: 18202396

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Note=Colocalizes with elongating RNA polymerase II (Pol II) on polytene chromosomes (PubMed:18202396).
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG3733

    STRING: 7227.FBpp0297122

    UniGene: Dm.2960