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  4. Recombinant Drosophila melanogaster Neurogenic locus protein delta (Dl), partial

Recombinant Drosophila melanogaster Neurogenic locus protein delta (Dl), partial

  • 中文名稱：
    黑腹果蠅Dl重組蛋白
  • 貨號：
    CSB-YP318005DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Dl重組蛋白
  • 貨號：
    CSB-EP318005DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Dl重組蛋白
  • 貨號：
    CSB-EP318005DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Dl重組蛋白
  • 貨號：
    CSB-BP318005DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Dl重組蛋白
  • 貨號：
    CSB-MP318005DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Dl
  • Uniprot No.：
  • 別名：
    Dl; CG3619; Neurogenic locus protein delta
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction.
  • 基因功能參考文獻(xiàn)：
    1. A new paramutation-like example at the Delta gene of Drosophila has been described. PMID: 28355214
    2. Binding of Notch to ligands of the Delta/DLL and Serrate/JAG families from neighboring cells leads to activation of the signaling pathway and is called trans-activation PMID: 28394891
    3. miR-124 plays neuroprotective roles in Alzheimer's disease Drosophila by targeting Delta in Notch signaling pathway. PMID: 26592243
    4. Notch activation by odorants depends on the Delta/Serrate/Lag2 ligand Delta in select olfactory receptor neurons. PMID: 21315258
    5. Differential Vegfr levels affect tip selection only in the presence of a functional Notch system by modulating the expression of the ligand Dll4. PMID: 20871601
    6. Delta is endocytosed in a Neuralized-dependent manner from the basolateral membrane. PMID: 20410139
    7. Dl transcription and protein levels did correlate with altered N signaling in mutant genotypes. PMID: 9651468
    8. results show that sna is required for the Neur-dependent endocytosis of Delta in the mesoderm, suggesting that Sna regulates the ability of mesodermal cells to signal and activate Notch receptors PMID: 12632175
    9. Delta is requiredfor the positioning of oocyte in the adjacent younger cyst. PMID: 14536057
    10. extension of planar filopodia is promoted by Delta; experimental suppression reduces Notch signalling in distant cells and increases bristle density in large proneural groups, showing these membrane specializations mediate long-range lateral inhibition PMID: 14654840
    11. two previously detected genotype/phenotype associations between bristle number and variants in the introns of Delta cannot be explained by linkage disequilibrium between these variants and nearby nonsynonymous variants PMID: 15020426
    12. Faf plays a role similar to that of Neur in the Delta signaling cells; by deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling PMID: 15469967
    13. Proteolytic cleavage of Dl by Kul represents a general mechanism for refining and maintaining the asymmetric distribution of Dl PMID: 15576412
    14. Altogether, these data support a model whereby proteolysis can modulate Delta ligand activity independently of endocytosis. PMID: 16487968
    15. the Hox genes, Sex combs reduced (Scr) and Ultrabithorax (Ubx), establish differential expression of the proneural gene achaete (ac) by modifying expression of the ac prepattern regulator, Delta (Dl), in T1 and T3 legs, respectively PMID: 17107776
    16. Fringe sensitizes Notch on glia to axon-derived Delta PMID: 17215308
    17. Delta loss-of-function alleles dominantly suppress Msk gain-of-function phenotypes in the developing wing. PMID: 17628519
    18. HNT functions in the determined R1/R6 precursor cells to allow Delta transcription to reach high enough levels at the right time to induce the cone-cell determinants Prospero and D-Pax2 in neighboring cells PMID: 19234063
    19. In R1/R6/R7 photoreceptor precursors, unidirectional signaling depends on Dl's ability to inhibit Notch within the same cell. Loss of Dl-mediated cis-inhibition reverses the direction of lateral signaling. PMID: 19631544
    20. suggests that within a NB lineage Delta is dispensable for sibling cell fate specification PMID: 19782677

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in all areas with neurogenic abilities, for example the neurogenic ectoderm and the primordia of the sense organs. Later expression is restricted to those cells that have adopted a neural fate.
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG3619

    STRING: 7227.FBpp0083153

    UniGene: Dm.7687