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  4. Recombinant Drosophila melanogaster Protein quiver (qvr)

Recombinant Drosophila melanogaster Protein quiver (qvr)

  • 中文名稱：
    黑腹果蠅qvr重組蛋白
  • 貨號：
    CSB-YP480381DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅qvr重組蛋白
  • 貨號：
    CSB-EP480381DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅qvr重組蛋白
  • 貨號：
    CSB-EP480381DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅qvr重組蛋白
  • 貨號：
    CSB-BP480381DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅qvr重組蛋白
  • 貨號：
    CSB-MP480381DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    qvr
  • Uniprot No.：
  • 別名：
    qvr; sss; CG33472; Protein quiver; Protein sleepless
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    33-127
  • 氨基酸序列
    ECQTRSIY CYECDSWTDA RCKDPFNYTA LPRDQPPLMT CNGCCVKMVR HQRSPYEVVR RMCTSQLQIN LFMVDHVCMM ESSGNGHMCF CEEDMCN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.
  • 基因功能參考文獻：
    1. QVR/SSS, and by extension perhaps other Ly6 proteins, target effector molecules using limited protein motifs. PMID: 26828958
    2. role in controlling excitability and synaptic transmission in fundamental processes of the nervous system such as sleep PMID: 24613312
    3. Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis. PMID: 24516136
    4. This study demonstrated that SLEEPLESS (SSS) protein modulates Shaker channel activity, possibly through a direct interaction at the plasma membrane. PMID: 21813698
    5. Two different functional states of Shaker I(A) current are observed in qvr larval muscles, as reflected by two distinct components differing in their kinetics of recovery from inactivation and sensitivity to a potassium channel blocker. PMID: 20429677
    6. The sleepless (sss) gene is required for sleep in Drosophila. It is proposed that SLEEPLESS is a signaling molecule that connects sleep drive to lowered membrane excitability. PMID: 18635795

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Quiver family
  • 組織特異性：
    Enriched in brain and head.
  • 數(shù)據(jù)庫鏈接：