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  4. Recombinant E3 ubiquitin-protein ligase ubr-1 (ubr-1), partial

Recombinant E3 ubiquitin-protein ligase ubr-1 (ubr-1), partial

  • 中文名稱：
    秀麗隱桿線蟲ubr-1重組蛋白
  • 貨號：
    CSB-YP309345CXY
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲ubr-1重組蛋白
  • 貨號：
    CSB-EP309345CXY
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲ubr-1重組蛋白
  • 貨號：
    CSB-EP309345CXY-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲ubr-1重組蛋白
  • 貨號：
    CSB-BP309345CXY
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲ubr-1重組蛋白
  • 貨號：
    CSB-MP309345CXY
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ubr-1
  • Uniprot No.：
  • 別名：
    ubr-1; C32E8.11; E3 ubiquitin-protein ligase ubr-1; EC 2.3.2.27; N-recognin-1; RING-type E3 ubiquitin transferase ubr-1; Ubiquitin-protein ligase E3-alpha
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. In complex with ced-3, required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 to regulate seam cell fate patterning during larval development. Negatively regulates glutamate metabolism through the aspartate aminotransferase got-1.2. Modulation of glutamate levels most likely controls locomotory behavior, in particular backwards locomotion or 'reversals'.
  • 基因功能參考文獻：
    1. results raise an intriguing possibility that UBR proteins regulate glutamate metabolism, which is critical for neuronal development and signaling PMID: 29649217
    2. show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples their in vivo activities, allowing for recognition and rapid degradation of LIN-28 PMID: 28602583
  • 亞細胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    UBR1 family
  • 組織特異性：
    Expressed in pharyngeal muscles, body wall muscles and a subset of neurons throughout postembryonic development. Prominently expressed in premotor interneurons, but not expressed in ventral cord motor neurons. Weakly expressed in hypodermal seam cells.
  • 數(shù)據(jù)庫鏈接：

    KEGG: cel:CELE_C32E8.11

    STRING: 6239.C32E8.11

    UniGene: Cel.5110