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Recombinant Grammostola rosea Kappa-theraphotoxin-Gr2c

  • 中文名稱：
    Recombinant Grammostola rosea Kappa-theraphotoxin-Gr2c,Yeast
  • 貨號：
    CSB-YP350337GDE
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Grammostola rosea Kappa-theraphotoxin-Gr2c,Yeast
  • 貨號：
    CSB-EP350337GDE
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Grammostola rosea Kappa-theraphotoxin-Gr2c,Yeast
  • 貨號：
    CSB-EP350337GDE-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Grammostola rosea Kappa-theraphotoxin-Gr2c,Yeast
  • 貨號：
    CSB-BP350337GDE
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Grammostola rosea Kappa-theraphotoxin-Gr2c,Yeast
  • 貨號：
    CSB-MP350337GDE
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    Kappa-theraphotoxin-Gr2c; Kappa-TRTX-Gr2c; GsAF II; GsAFII; GsAf2; Mechanotoxin-alpha
  • 種屬：
    Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
  • 蛋白長度：
    Cytoplasmic domain
  • 表達區(qū)域：
    51-81
  • 氨基酸序列
    YCQKWMWTCD EERKCCEGLV CRLWCKKKIE W
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibits sodium channels Nav1.1/SCN1A (IC(50)=5.7 uM), Nav1.2/SCN2A (IC(50)=12 uM), Nav1.4/SCN4A (IC(50)=4 uM), Nav1.6/SCN8A (IC(50)=6.6 uM), Nav1.7/SCN9A (IC(50)=13.6-1030 nM), potassium channels Kv11.1/KCNH2 (IC(50)=4.7 uM), as well as high-voltage-gated calcium channels Cav1.2/CACNA1C (IC(50)= nM). Also blocks mechanosensitive ion channels (also named stretch-activated channels or SACs) and the hypotonic cell swelling induced calcium increase associated with the activation of such channels (Ref.3). It can thus be useful in treating cardiac ventricular disturbances (Ref.3). Also induces analgesia in mammals (Ref.2).
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Phrixotoxin family
  • 組織特異性：
    Expressed by the venom gland.