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  4. Recombinant Helicobacter pylori Cytotoxicity-associated immunodominant antigen (cagA), partial

Recombinant Helicobacter pylori Cytotoxicity-associated immunodominant antigen (cagA), partial

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  • 中文名稱：
    Recombinant Helicobacter pylori Cytotoxicity-associated immunodominant antigen(cagA),partial
  • 貨號：
    CSB-EP345531HUV
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    cagA
  • Uniprot No.：
  • 別名：
    cagA; cag26; cai; HP_0547Cytotoxicity-associated immunodominant antigen; 120 kDa protein; CAG pathogenicity island protein 26
  • 種屬：
    Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    37.6 kDa
  • 表達區(qū)域：
    1-294aa
  • 氨基酸序列
    MTNETIDQTRTPDQTQSQTAFDPQQFINNLQVAFIKVDNVVASFDPDQKPIVDKNDRDNRQAFDGISQLREEYSNKAIKNPTKKNQYFSDFIDKSNDLINKDNLIDVESSTKSFQKFGDQRYQIFTSWVSHQKDPSKINTRSIRNFMENIIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGGPTGGDWLDIFLSFIFNKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be necessary for the transcription, folding, export, or function of the cytotoxin.
  • 基因功能參考文獻：
    1. The authors conclude that CagQ is a membrane protein in a type IV secretion system and is crucial for maintaining CagA expression and CagA-induced apoptotic effects. PMID: 29306012
    2. The vacuolating cytotoxin autotransporter (vacA) c1 genotype, but not cytotoxicity-associated immunodominant antigen (cagA) status, might be the first important bacterial biomarker for predicting the cardia adenocarcinoma risk. PMID: 29036792
    3. In this study, through quantitative analysis of the complex formation between CagA and PAR1b, the authors found that several CagA species have acquired elevated PAR1b-binding activity via duplication of the CagA multimerization motifs, while others have lost their PAR1b-binding activity. PMID: 27445265
    4. Helicobacter pylori expressing cagA and vacA genes is prevalent in dyspeptic Ghanaian patients. PMID: 28655347
    5. H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells. PMID: 28082808
    6. Data indicate that treatment of gastric epithelial cells with simvastatin reduced the level of cellular cholesterol and led to attenuation of translocation and phosphorylation of cytotoxin-associated gene A (CagA). PMID: 26730715
    7. Studies suggest that cytotoxin-associated gene A (CagA)-negative non-virulent strains of Helicobacter pylori may be a potential risk factor of pancreatic cancer. PMID: 26390415
    8. CagT plays an important role in the translocation of CagA into host epithelial cells. PMID: 23075784
    9. CagA upregulated CIP2A expression and this upregulation effect was dependent on Src and Ras/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways. PMID: 19959630
    10. In a stomach adenocarcinoma cell line, an increase in this protein correlated with the amount of the phosphorylated protein. PMID: 16278423
    11. These data demonstrate that VacA can downregulate CagA's effects on epithelial cells, a novel molecular mechanism showing how H. pylori can avoid excessive cellular damage. PMID: 19046339

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