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Recombinant Human 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13)

In Stock
  • 中文名稱：
    人HSD17B13重組蛋白
  • 貨號(hào)：
    CSB-YP801815HU
  • 規(guī)格：
    ￥2208
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    HSD17B13
  • Uniprot No.：
  • 別名：
    HSD17B13; SCDR9; SDR16C3; HMFN0376; UNQ497/PRO1014; 17-beta-hydroxysteroid dehydrogenase 13; 17-beta-HSD 13; EC 1.1.-.-; Short chain dehydrogenase/reductase family 16C member 3; Short-chain dehydrogenase/reductase 9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein of Isoform 2
  • 來源：
    Yeast
  • 分子量：
    34.8 kDa
  • 表達(dá)區(qū)域：
    20-300aa
  • 氨基酸序列
    ESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer，50% glycerol
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    To produce recombinant Human HSD17B13 protein, a well-established recombinant DNA technology is the key. A DNA template of HSD17B13 was constructed with N-terminal 6xHis tag & C-terminal Myc tag using the technique. Once the template was made, the recombinant Human HSD17B13 protein could be produced with it efficiently. CUSABIO has built a strict QC system to ensure quality. The expression region is 20-300aa of the Human HSD17B13. The purity of this recombinant is 90% determined by SDS-PAGE.

    HSD17B13 (SCDR9) is a protein coding gene that encodes 17-beta-hydroxysteroid dehydrogenase 13. According to some studies, HSD17B13 may have the following features.
    Loss-of-function variants of HSD17B13 are associated with a reduced risk of chronic liver disease and progression from steatohepatitis to steatohepatitis. Inactivation of HSD17B13 was not associated with increased hepatic triglyceride content and provided protection against chronic liver disease. HSD17B13, a hepatic retinol dehydrogenase, is associated with histological features of nonalcoholic fatty liver disease. Lack of Hsd17b13 did not protect mice from an obesogenic diet. High risk of fatty liver amplifies the alanine aminotransferase-lowering effect of HSD17B13 variants. Genetic variants in HSD17B13 reduce the risk of cirrhosis and hepatocellular carcinoma in alcohol abusers.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Lower HSD17B13 in peritumoral tissues was associated with worse recurrence free survival and overall survival of hepatocellular carcinoma patients and altered G1/S progression of HCC cells. PMID: 29748147
    2. We conducted a test for association between the rs72613567:TA variant and protection against severe liver fibrosis in 88 patients of Caucasian descent with HCV monoinfection. We conclude that rs72613567:TA is correlated with protection against liver fibrosis associated with HCV infection. PMID: 30403944
    3. A loss-of-function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis. PMID: 29562163
    4. 17beta-HSD13 as a pathogenic protein in the development of nonalcoholic fatty liver disease. PMID: 25028495
    5. A new human short-chain dehydrogenase/reductase gene SCDR9 is cloned and expressed. PMID: 17311113

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum. Lipid droplet.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18685

    OMIM: 612127

    KEGG: hsa:345275

    STRING: 9606.ENSP00000333300

    UniGene: Hs.284414