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  4. Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial

Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial

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  • 中文名稱：
    Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(CD38),partial
  • 貨號(hào)：
    CSB-MP004929HU1
  • 規(guī)格：
    ￥3000
  • 促銷：
    現(xiàn)貨重組蛋白特價(jià)促銷
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD antigen CD38
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Extracellular Domain
  • 來(lái)源：
    Mammalian cell
  • 分子量：
    57.4 kDa
  • 表達(dá)區(qū)域：
    43-300aa
  • 氨基酸序列
    VPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    C-terminal hFc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer，50% glycerol
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    CUSABIO synthesized the recombinant gene by integrating the C-terminal hFc tag sequence into the targeted gene encoding the 43-300aa of the human CD38. The synthesized gene was subsequently cloned into an expression vector. After cloning, the expression vector was introduced into the Mammalian cell for expression. The product was purified to obtain the recombinant human CD38 protein carrying C-terminal hFc tag. The SDS-PAGE assayed the purity of this recombinant CD38 protein greater than 85%. This CD38 protein migrated along the gel to a band of about 58-90 kDa molecular weight.

    CD38 is a gene providing instruction of making a protein named ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (also abbreviated as ADPRC1 or CD38) in human and belongs to ADP-ribosyl cyclase family. CD38 is a type II transmembrane glycoprotein and the receptor of CD31. The combination of CD38 and CD31 plays an important role in cell migration and receptor-mediated adhesion. On the surface of lymphoid cells, myeloid cells and other non-hematopoietic tissue cells, the expression of CD38 shows is lower, but on the surface of malignant plasma cells such as myeloma cells, CD38 shows high expression. With this feature, CD38 has become a popular target for the treatment of multiple myeloma (MM).

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

平均分:
5.0分 - 1 個(gè)評(píng)價(jià)

實(shí)驗(yàn)應(yīng)用：ELISA標(biāo)準(zhǔn)品

產(chǎn)品評(píng)價(jià)： 這個(gè)蛋白純度高，活力好，不管是做ELISA還是活性實(shí)驗(yàn)都很順利，價(jià)格有優(yōu)惠，服務(wù)也好！

By 董老師

靶點(diǎn)詳情

  • 功能：
    Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
  • 基因功能參考文獻(xiàn)：
    1. CD38 and cADPR are key players in the orches- tration of cellular responses to respiratory syncytial virus by infected monocyte-derived dendritic cells. PMID: 29178427
    2. our data are consistent with the conclusion that CD38 plays a role in murine and human lung tumorigenesis PMID: 29228209
    3. isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma PMID: 28249894
    4. Empathic response mediates the CD38-altruism association. PMID: 28865941
    5. Increased levels of HLADR and CD38 expressions in peripheral blood were associated with oral lesions in HIV-positive patients. Periodontal disease was associated with HLADR expression. PMID: 28500735
    6. Panobinostat increased CD38 expression in a dose-dependent manner in primary myeloma cells. This was specific for myeloma cells and did not occur in lymphoma cell lines. This increase enabled the antimyeloma activity of daratumumab. PMID: 28476749
    7. To demonstrate the therapeutic effect of daratumumab in CLL, we generated a disseminated CLL mouse model with the CD38(+) MEC2 cell line and CLL patient-derived xenografts (CLL-PDX). Daratumumab significantly prolonged overall survival of MEC2 mice, completely eliminated cells from the infiltrated organs, and significantly reduced disease burden in the spleen of CLL-PDX PMID: 27637890
    8. CD38 mRNA levels were correlated with lower Autism Quotient (AQ), indicating enhanced social skills. CD38 expression and CD157 eQTL SNPs altogether account for a substantial 14% of the variance in sociality. the ecological validity of these findings was demonstrated with subjects with higher PBL CD38 expression having more friends, especially for males. PMID: 28212520
    9. CD38(lo) luminal cells are enriched in glands adjacent to inflammatory cells and exhibit epithelial nuclear factor kappaB (NF-kappaB) signaling. In response to oncogenic transformation, CD38(lo) luminal cells can initiate human prostate cancer in an in vivo tissue-regeneration assay PMID: 27926864
    10. Results provide evidence that CD38 enhanced the proliferation and inhibited the apoptosis of cervical cancer cells by affecting the mitochondria functions. PMID: 28544069
    11. these data demonstrate an important role for CD38 and complement-inhibitory protein expression levels in daratumumab sensitivity. PMID: 27307294
    12. Results may imply that CD38 expression either reflects or participates in pathogenic mechanisms of HIV disease independently of cell cycling. PMID: 27064238
    13. The data suggest that ZO-1, along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring. PMID: 26306999
    14. Primary human melanoma cell lines suppress in vitro T cell proliferation through an adenosinergic pathway in which CD38 and CD73 play a prominent role. PMID: 26329660
    15. CD38 and its related genes are highly expressed in human nasopharyngeal carcinoma cell lines. PMID: 25630761
    16. soluble CD38 (sCD38) in seminal plasma increases the capacitation of sperm via specific interactions between sCD38 and the CD31 on the sperm. PMID: 26407101
    17. the expression of CD38+ on both CD4+, CD8+T lymphocytes from peripheral blood and CSF discriminated between viremic and non-viremic patients PMID: 26365593
    18. study points to an association between maternal SNPs in the CD38 in Japanese women and susceptibility to preterm birth. PMID: 26025338
    19. Peripheral blood CD38 bright CD8+ effector memory T cells predict acute graft-versus-host disease. PMID: 25881755
    20. CD38 is expressed on human MDSC-like cell population that is expanded in the peripheral blood of advanced-stage cancer patients. PMID: 26294209
    21. Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab. PMID: 25975191
    22. Genetic variation in CD38 and breastfeeding experience interact to impact infants' attention to social eye cues. PMID: 26371313
    23. genetic polymorphism is associated with diffuse large B-cell lymphoma susceptibility in Egyptians PMID: 25564959
    24. Hairy-cell leukemia patients that were CD38-positive had a shorter mean time to salvage therapy than CD38-negative ones. CD38 expression in HCL drives poor prognosis by promoting survival and heterotypic adhesion. PMID: 26170397
    25. alterations in content of soluble molecules CD38 are associated with characteristics of tumor process that indicates at their monitoring significance under malignant neoplasms of uterus PMID: 26470437
    26. The results indicate that the net charge of the N-terminal segment is important in determining the membrane topology of CD38 and that the type III orientation can be a functional form of CD38 for Ca(2)-signaling. PMID: 25447548
    27. The majority of extranodal NK/T cell lymphoma cases were CD38 positive, which significantly correlated with poor outcomes. PMID: 25865943
    28. High levels of CD38 reduced intracellular (NAD+) levels and blocked acquired resistance by inhibiting the activity of the NAD+-dependent SIRT1 deacetylase PMID: 24967705
    29. CD38 status was associated with behavior and psychological reactions within live interactions, as well as global relationship quality PMID: 24396004
    30. These results validate CD38 as a therapeutic target and support the current evaluation of this unique CD38-targeting functional antibody in phase I clinical trials in patients with CD38+ B-cell malignancies. PMID: 24987056
    31. At the same time, CD38 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo PMID: 25310288
    32. CD38 expression is regulated by micro-RNA 708 in airway smooth muscle cells. PMID: 25175907
    33. CD38 has a role in chronic lymphocytic leukemia growth and trafficking PMID: 24990614
    34. Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-gamma by a T-bet-dependent mechanism. PMID: 25505279
    35. Increased numbers of circulating ICOS(+) and IL-21(+) Tfh and CD38(+) plasma cells may be exhibited by patients with recent diagnoses of primary biliary cirrhosis. PMID: 25404409
    36. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38 PMID: 24635660
    37. Autism and features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
    38. results demonstrate that CD38(+) cells are a useful model to study effects of the cellular NAD levels on cellular processes and establish a new linker between cellular NAD levels and oxidative stress PMID: 24295520
    39. only one SNP in CD38 was significantly associated with social integration and that SNP predicted when using a dichotomized indicator of social connectedness, but not a continuous measure of social connectedness or the continuously married outcome. PMID: 24209975
    40. Data suggest that the uniquely increased expression of CD38 and E2F2 in rheumatoid arthritis (RA) synovial tissues contribute to the immunoactivation of the disease. PMID: 24397353
    41. PBMC from MM patients display a deregulated response related to CD38 activation pathway defects; CD38 may be functionally involved in the progression of this pathology via the secretion of high levels of IL-6 that protects neoplastic cells from apoptosis PMID: 24489445
    42. These data suggest that both functional roles of CD38 might be important in the pathogenesis of B-CLL. PMID: 24216102
    43. Atorvastatin and rosiglitazone did not affect the expression of CD38. PMID: 23686733
    44. Data suggest CD38 (CD38 antigen (p45) protein) and CD49d (alpha4 Integrin; very late antigen-4 alpha) are more than just markers of an aggressive chronic lymphocytic leukemia (CLL) cell type and play functional roles in pathobiology of CLL. [REVIEW] PMID: 24288111
    45. CD38 is expressed within caveolae and its function is linked to the caveolar regulatory proteins. PMID: 24275509
    46. Report diagnosis of multiple myeloma using two-color flow cytometry based on kappa/lambda ratios of CD38-gated plasma cells. PMID: 23755763
    47. CD38-cADPR mediates bile acid-induced pancreatitis and acinar cell injury through aberrant intracellular Ca(2+) signaling. PMID: 23940051
    48. The frequency of CD38high antibody-secreting cells (ASCs) is increased during the acute phase of hepatitis A virus (HAV) infection. Substantial numbers of ASCs are non-HAV-specific and dominantly secrete IgM. PMID: 23729443
    49. Data show that ADP-ribosylation of CtBP1-S/BARS by brefeldin A (BFA) occurs via synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. PMID: 23716697
    50. CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells. PMID: 22955446

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    ADP-ribosyl cyclase family
  • 組織特異性：
    Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1667

    OMIM: 107270

    KEGG: hsa:952

    STRING: 9606.ENSP00000226279

    UniGene: Hs.479214