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Recombinant Human ALK and LTK ligand 2 (ALKAL2)

  • 中文名稱：
    Recombinant Human ALK and LTK ligand 2(ALKAL2),Yeast
  • 貨號：
    CSB-YP740918HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human ALK and LTK ligand 2(ALKAL2),Yeast
  • 貨號：
    CSB-EP740918HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human ALK and LTK ligand 2(ALKAL2),Yeast
  • 貨號：
    CSB-MP740918HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ALKAL2
  • Uniprot No.：
  • 別名：
    ALKAL2; FAM150B; UNQ542/PRO1097; ALK and LTK ligand 2; Augmentor alpha; AUG-alpha; Protein FAM150B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    25-152
  • 氨基酸序列
    GAEPRE PADGQALLRL VVELVQELRK HHSAEHKGLQ LLGRDCALGR AEAAGLGPSP EQRVEIVPRD LRMKDKFLKH LTGPLYFSPK CSKHFHRLYH NTRDCTIPAY YKRCARLLTR LAVSPVCMED KQ
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.
  • 基因功能參考文獻：
    1. activation of ALK/LTK family receptors by small ALKAL proteins (FAM150, AUG) conserved in vertebrates PMID: 29317532
    2. In conclusion, these data show that ALK is robustly activated by the FAM150A/B ligands. PMID: 26418745
    3. Data show FAM150B, which was named as augmentor-alpha (AUG-alpha), binds and activtes both anaplastic lymphoma kinase (ALK) and tyrosine kinase (LTK). PMID: 26630010
    4. Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation. PMID: 25331893
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    ALKAL family
  • 組織特異性：
    Widely expressed with highest levels in adrenal gland and modest levels in pancreas, testis and uterus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 27683

    KEGG: hsa:285016

    STRING: 9606.ENSP00000384604

    UniGene: Hs.355207