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  4. Recombinant Human AP-1 complex subunit beta-1 (AP1B1), partial

Recombinant Human AP-1 complex subunit beta-1 (AP1B1), partial

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  • 中文名稱：
    Recombinant Human AP-1 complex subunit beta-1(AP1B1),partial
  • 貨號：
    CSB-EP604616HU
  • 規(guī)格：
    ￥1836
  • 圖片：
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP604616HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AP1B1.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP604616HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AP1B1.
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    AP1B1
  • Uniprot No.：
  • 別名：
    Adaptin; beta 2 (beta); Adaptor protein complex AP-1 subunit beta-1; Adaptor related protein complex 1; beta 1 subunit; Adaptor related protein complex 2; beta 1 subunit; Adaptor-related protein complex 1 subunit beta-1; ADTB1; ADTB2; AP 1 complex subunit beta 1; AP 2 complex subunit beta 1; AP-1 complex subunit beta-1; AP1 Beta; AP1B1; AP1B1_HUMAN; AP2 Beta; AP2B1; Beta-1-adaptin; Beta-adaptin 1; Beta1 adaptin; Beta2 adaptin; CLAPB1; CLAPB2; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    73.3 kDa
  • 表達區(qū)域：
    1-584aa
  • 氨基酸序列
    MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 6xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer，50% glycerol
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
  • 基因功能參考文獻：
    1. both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 are capable of carrying out basolateral sorting of ClC-2. PMID: 25739457
    2. AP1B regulates basolateral EGFR membrane delivery predominantly in the biosynthetic route in MDCK cells monolayers. PMID: 23205726
    3. The conclude that in addition to its role in endocytosis, ARH cooperates with AP-1B in basolateral exocytosis of LDLR from recycling endosomes. PMID: 21444685
  • 亞細胞定位：
    Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • 蛋白家族：
    Adaptor complexes large subunit family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 554

    OMIM: 600157

    KEGG: hsa:162

    STRING: 9606.ENSP00000350199

    UniGene: Hs.368794