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Recombinant Human Cdc42 effector protein 2 (CDC42EP2)

  • 中文名稱：
    Recombinant Human Cdc42 effector protein 2(CDC42EP2),Yeast
  • 貨號：
    CSB-YP005013HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cdc42 effector protein 2(CDC42EP2),Yeast
  • 貨號：
    CSB-EP005013HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cdc42 effector protein 2(CDC42EP2),Yeast
  • 貨號：
    CSB-EP005013HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cdc42 effector protein 2(CDC42EP2),Yeast
  • 貨號：
    CSB-BP005013HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cdc42 effector protein 2(CDC42EP2),Yeast
  • 貨號：
    CSB-MP005013HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CDC42EP2
  • Uniprot No.：
  • 別名：
    Binder of Rho GTPases 1; BORG1; BORG1_HUMAN; CDC42 effector protein (Rho GTPase binding) 2; Cdc42 effector protein 2; Cdc42ep2; CEP2; CRIB-containing BOGR1 protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-210
  • 氨基酸序列
    STKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGSD MFGDISFLQG KFHLLPGTMV EGPEEDGTFD LPFQFTRTAT VCGRELPDGP SPLLKNAISL PVIGGPQALT LPTAQAPPKP PRLHLETPQP SPQEGGSVDI WRIPETGSPN SGLTPESGAE EPFLSNASSL LSLHVDLGPS ILDDVLQIMD QDLDSMQIPT
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling. PMID: 27913681
    2. CDC42EP2 is upregulated in human PDLCs subjected to tensile stress related to mechano-induced cell cycle arrest. PMID: 20934684
    3. activations of Rac1 and Cdc42 are involved in the hypoxia-induced production of angiogenesis-promoting factors and tumor suppressors, and suggest that the Rho family GTPases Rac1 and Cdc42 may contribute to the hypoxia-mediated angiogenesis. PMID: 16395716
  • 亞細(xì)胞定位：
    Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    BORG/CEP family
  • 組織特異性：
    Highly expressed in the heart. Weakly expressed in the pancreas and liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16263

    OMIM: 606132

    KEGG: hsa:10435

    STRING: 9606.ENSP00000279249

    UniGene: Hs.343380