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  4. Recombinant Human Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1), partial

Recombinant Human Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1), partial

  • 中文名稱：
    Recombinant Human Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1), partial
  • 貨號：
    CSB-MP747637HU1
  • 規(guī)格：
    ￥1908
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    CCBE1
  • Uniprot No.：
  • 別名：
    Full of fluid protein homolog
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    39.0 kDa
  • 表達區(qū)域：
    159-250aa
  • 氨基酸序列
    CECREGYIREDDGKTCTRGDKYPNDTGHEKSENMVKAGTCCATCKEFYQMKQTVLQLKQKIALLPNNAADLGKYITGDKVLASNTYLPGPPG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    C-terminal hFc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
  • 基因功能參考文獻：
    1. the present results demonstrated that CCBE1 expression was downregulated in lung cancer, particularly in the presence of LNM. PMID: 29207117
    2. these data indicated that CCBE1 may be served as a new predictor of prognosis in post-operative gastrointestinal stromal tumor patients and may play an important role in stimulating tumor progression PMID: 27506146
    3. We identify CCBE1 as a direct target of miR-330-3p, and show that knockdown of CCBE1 results in a greater invasive capacity. Accordingly, in breast cancer patients CCBE1 is frequently downregulated, and its loss is associated with reduced distant relapse-free and overall survival. PMID: 28419078
    4. characterization of Hennekam Syndrome phenotypes in two Turkish siblings with protein mutation PMID: 26686525
    5. Collagen domains of CCBE1 are crucial for the activation of VEGFC in vitro and in vivo. The EGF domains of CCBE1 are dispensable for regulation of VEGFC processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo. PMID: 25814692
    6. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. PMID: 24552833
    7. Both siblings harbored a homozygous mutation in CCBE1. PMID: 24086631
    8. The study has shown that CCBE1 mutations are not a major contributor to non-immune hydrops fetalis. PMID: 22239599
    9. Human CCBE1 strongly enhances vascular endothelial growth factor-C-mediated lymphangiogenesis in a corneal micropocket assay PMID: 21778431
    10. Loss of CCBE1 expression may promote ovarian carcinogenesis by enhancing migration & cell survival. CCBE1 is a new candidate tumour suppressor in ovarian cancer. PMID: 19935792
    11. Homozygous cysteine to serine change and SNPS in CCBE1 were identified patients. PMID: 19911200
    12. Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans PMID: 19935664

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  • 相關(guān)疾?。?/div>
    Hennekam lymphangiectasia-lymphedema syndrome 1 (HKLLS1)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    CCBE1 family
  • 組織特異性：
    Not expressed in blood or lymphatic endothelial cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29426

    OMIM: 235510

    KEGG: hsa:147372

    STRING: 9606.ENSP00000404464

    UniGene: Hs.34333