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Recombinant Human Cyclin-dependent kinase 13 (CDK13), partial

  • 中文名稱：
    Recombinant Human Cyclin-dependent kinase 13(CDK13) ,partial,Yeast
  • 貨號：
    CSB-YP613482HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cyclin-dependent kinase 13(CDK13) ,partial,Yeast
  • 貨號：
    CSB-EP613482HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cyclin-dependent kinase 13(CDK13) ,partial,Yeast
  • 貨號：
    CSB-EP613482HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cyclin-dependent kinase 13(CDK13) ,partial,Yeast
  • 貨號：
    CSB-BP613482HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cyclin-dependent kinase 13(CDK13) ,partial,Yeast
  • 貨號：
    CSB-MP613482HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CDK13
  • Uniprot No.：
  • 別名：
    CDC2 related protein kinase 5; CDC2-related protein kinase 5; CDC2L; CDK13; CDK13_HUMAN; cell division controller cholinesterase related; cell division cycle 2 like 5 (cholinesterase related cell division controller); cell division cycle 2 like 5; Cell division cycle 2 like protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; CHED; Cholinesterase related cell division controller; Cholinesterase-related cell division controller; cyclin dependent kinase 13; Cyclin-dependent kinase 13; hCDK13
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

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靶點詳情

  • 功能：
    Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
  • 基因功能參考文獻(xiàn)：
    1. Heterozygous constitutional CDK13 mutations in 3 patients cause intellectual disability without cardiac defects. PMID: 29222009
    2. CDK13 RNA over-editing sites mediated by ADAR1 may serve as novel cancer driver events in HCC progression. PMID: 29996118
    3. heterozygous, likely dominant negative mutations affecting the protein kinase domain of the CDK13 gene result in a recognisable, syndromic form of intellectual disability, with or without congenital heart disease. PMID: 29021403
    4. Mutation in CHK13 gene is associated with congenital heart defects. PMID: 27479907
    5. Detailed phenotypic and molecular characterisation of 9 individuals with pathogenic variants in CDK13 is provided. Two individuals had novel CDK13 variants (p.Asn842Asp, p.Lys734Glu), while the remaining seven unrelated individuals had a recurrent, previously published p.Asn842Ser variant. PMID: 28807008
    6. CDK13 gene is amplified in different types of cancer indicate that this kinase can contribute to cancer development in human. PMID: 26886422
    7. CDK12 and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response. PMID: 25561469
    8. High CDK13 expression is associated with pancreatic cancer. PMID: 25216700
    9. Coincidently amplified CDK13, GMNN, and CENPF genes can play a role as common cancer-driver genes in human cancers. PMID: 22912832
    10. CDK13 interacts with cyclin K, and is required for self-renewal in ES cells. PMID: 22547058
    11. Data demonstrate that CDC2L5 is located in the nucleoplasm, where it directly interacts with the ASF/SF2-associated protein p32, a protein involved in splicing regulation. PMID: 16721827

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  • 相關(guān)疾?。?/div>
    Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD)
  • 亞細(xì)胞定位：
    Nucleus speckle.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性：
    Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1733

    OMIM: 603309

    KEGG: hsa:8621

    STRING: 9606.ENSP00000181839

    UniGene: Hs.233552